SRSF1

Gene Symbol SRSF1
Entrez Gene 6426
Alt Symbol ASF, SF2, SF2p33, SFRS1, SRp30a
Species Human
Gene Type protein-coding
Description serine/arginine-rich splicing factor 1
Other Description SR splicing factor 1|alternative-splicing factor 1|pre-mRNA-splicing factor SF2, P33 subunit|splicing factor 2|splicing factor, arginine/serine-rich, 30-KD, A
Swissprots B2R6Z7 D3DTZ3 Q13809 Q07955
Accessions EAW94485 EAW94486 EAW94487 EAW94488 EAW94489 EAW94490 EAW94491 EAW94492 Q07955 AB062124 BAB93456 AB209558 BAD92795 AK054610 AK095112 AK126318 BAC86523 AK225711 AK289933 BAF82622 AK298527 BAH12806 AK312781 BAG35644 BC010264 AAH10264 BC033785 AAH33785 CB044653 DA939911 HG509274 M69040 AAA03476 M72709 AAA35564 XM_006722012 XP_006722075 XR_429911 XR_429912 NM_001078166 NP_001071634 NM_006924 NP_008855 NR_034041
Function Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.
Subcellular Location Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Top Pathways Spliceosome, Herpes simplex infection

Human-SFRS1-cDNA-Clone - DC02891 from Abgent, a WuXi AppTec company

Prices $334.80
Sizes 10 µg
Species Human
Accession BC010264

SRSF1 cDNA (ANA11117) - ANA11117 from Aviva Systems Biology

Prices $189.00
Sizes 1 µg
Accession NM_006924.4

Human SFRS1 ORF Clone(NM_006924.4) - CDCL175226 from Creative Biomart

Species Human
Accession NM_006924.4

Human SFRS1 ORF Clone(NM_001078166.1) - CDCL175227 from Creative Biomart

Species Human
Accession NM_001078166.1

Human SRSF1 cDNA clone(NM_001078166.1) - CDFH018656 from Creative Biomart

Species Human
Accession NM_001078166.1

Human SRSF1 cDNA clone(NM_006924.4) - CDFH018657 from Creative Biomart

Species Human
Accession NM_006924.4

Human SRSF1 ORF Clone(NM_006924.4) - CDCR294031 from Creative Biomart

Species Human
Accession NM_006924.4

Human SRSF1 ORF Clone(NM_006924.4) - CDCR294032 from Creative Biomart

Species Human
Accession NM_006924.4

Human SRSF1 ORF Clone(NM_006924.4) - CDCR294033 from Creative Biomart

Species Human
Accession NM_006924.4

Human SRSF1 ORF Clone(NM_001078166.1) - CDCR345302 from Creative Biomart

Species Human
Accession NM_001078166.1

Human SRSF1 ORF Clone(NM_001078166.1) - CDCR345303 from Creative Biomart

Species Human
Accession NM_001078166.1

Human SRSF1 ORF Clone(NM_001078166.1) - CDCR345304 from Creative Biomart

Species Human
Accession NM_001078166.1

human SRSF1 ORF clone - CDCH079276 from Creative Biomart

Species Human
Accession NM_001078166

human SRSF1 ORF clone - CDCH079277 from Creative Biomart

Species Human
Accession NM_001078166

human SRSF1 ORF clone - CDCH079278 from Creative Biomart

Species Human
Accession NM_001078166

human SRSF1 ORF clone - CDCH079279 from Creative Biomart

Species Human
Accession NM_001078166

Human SRSF1 Gene cDNA clone plasmid - HG14651-G from Sino Biological

Species Human
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