SRSF1

Gene Symbol	SRSF1
Entrez Gene	6426
Alt Symbol	ASF, SF2, SF2p33, SFRS1, SRp30a
Species	Human
Gene Type	protein-coding
Description	serine/arginine-rich splicing factor 1
Other Description	SR splicing factor 1|alternative-splicing factor 1|pre-mRNA-splicing factor SF2, P33 subunit|splicing factor 2|splicing factor, arginine/serine-rich, 30-KD, A
Swissprots	B2R6Z7 D3DTZ3 Q13809 Q07955
Accessions	EAW94485 EAW94486 EAW94487 EAW94488 EAW94489 EAW94490 EAW94491 EAW94492 Q07955 AB062124 BAB93456 AB209558 BAD92795 AK054610 AK095112 AK126318 BAC86523 AK225711 AK289933 BAF82622 AK298527 BAH12806 AK312781 BAG35644 BC010264 AAH10264 BC033785 AAH33785 CB044653 DA939911 HG509274 M69040 AAA03476 M72709 AAA35564 XM_006722012 XP_006722075 XR_429911 XR_429912 NM_001078166 NP_001071634 NM_006924 NP_008855 NR_034041
Function	Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.
Subcellular Location	Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Top Pathways	Spliceosome, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SFRS1 293T Cell Transient Overexpression Lysate(Denatured) - H00006426-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SFRS1 293 Cell Lysate - 401825 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SF2 Overexpression Lysate (Denatured) - H00006426-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

SF2 Overexpression Lysate (Native) - NBL1-15886 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SRSF1 Over-expression Lysate Product - GWB-BC323F from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SF2 Overexpression Lysate (Native) - NBP2-11448 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SF2 Overexpression Lysate (Native) - NBP2-10637 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human SRSF1 Knockdown Stable Cell Line - CSC-DC015176 from Creative biogene Category Cell Line Species Human

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