SRSF1

Gene Symbol	SRSF1
Entrez Gene	6426
Alt Symbol	ASF, SF2, SF2p33, SFRS1, SRp30a
Species	Human
Gene Type	protein-coding
Description	serine/arginine-rich splicing factor 1
Other Description	SR splicing factor 1|alternative-splicing factor 1|pre-mRNA-splicing factor SF2, P33 subunit|splicing factor 2|splicing factor, arginine/serine-rich, 30-KD, A
Swissprots	B2R6Z7 D3DTZ3 Q13809 Q07955
Accessions	EAW94485 EAW94486 EAW94487 EAW94488 EAW94489 EAW94490 EAW94491 EAW94492 Q07955 AB062124 BAB93456 AB209558 BAD92795 AK054610 AK095112 AK126318 BAC86523 AK225711 AK289933 BAF82622 AK298527 BAH12806 AK312781 BAG35644 BC010264 AAH10264 BC033785 AAH33785 CB044653 DA939911 HG509274 M69040 AAA03476 M72709 AAA35564 XM_006722012 XP_006722075 XR_429911 XR_429912 NM_001078166 NP_001071634 NM_006924 NP_008855 NR_034041
Function	Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'- CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. {ECO:0000269|PubMed:8139654}.
Subcellular Location	Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.
Top Pathways	Spliceosome, Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SF2 full length protein - ab82611 from Abcam Category Protein Source Baculovirus Species Human

Human SF2 full length protein - ab82026 from Abcam Category Protein Source E. coli Species Human

Human SF2 peptide - ab38811 from Abcam Category Peptide

Human SF2 peptide - ab38812 from Abcam Category Peptide

SFRS1 / SF2 Antibody Blocking Peptide - LS-E14905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFRS1 / SF2 Antibody Blocking Peptide - LS-E8505 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFRS1 / SF2 Antibody Blocking Peptide - LS-E8506 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SF2 Protein - H00006426-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SFRS1-Antibody-C-term-Blocking-Peptide - BP6857b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFRS1-Antibody-N-term-Blocking-Peptide - BP6857a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SRSF1 Protein Lysate (APL11117) - APL11117 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human SRSF1 protein - orb244537 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human SRSF1 protein - orb169355 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

SFRS1 Blocking Peptide - 33R-3658 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SFRS1 Blocking Peptide - 33R-2415 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SFRS1 protein (His tag) - 80R-2653 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

SFRS1 (SF2) (1-248, His-tag) - AR50773PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SFRS1 (SF2) (1-248, His-tag) - AR50773PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SFRS1 (SF2) - H00006426-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SFRS1 (SF2) - H00006426-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SFRS1, 1-248aa Human, His tag, E.coli - 01-P1949 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

ASF/SF2 fusion protein - Ag3626 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Splicing Factor, Arginine/Serine-rich 1 - SFRS1-1014H from Creative Biomart Category Protein Source E. coli.

Recombinant Human Splicing Factor, Arginine/Serine-rich 1 - SFRS1-1015H from Creative Biomart Category Protein Source Sf9 insect cells.

Recombinant Human SRSF1, His-tagged - SRSF1-8494H from Creative Biomart Category Protein Source Sf21 Cells Species Human

Search more