NR1I2

Gene Symbol	NR1I2
Entrez Gene	8856
Alt Symbol	BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group I, member 2
Other Description	nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PAR1|orphan nuclear receptor PXR|pregnane X nuclear receptor variant 2|pregnane X receptor|steroid and xenobiotic receptor
Swissprots	Q9UJ27 Q9UJ22 Q006P5 Q9UJ25 Q008C8 Q9UJ24 Q96AC7 O75469 Q9UJ26 Q9UNW4 Q9UJ23
Accessions	AAG23345 AAK38720 AAK38721 AAK38722 ABJ52965 ABJ52966 ABR09276 EAW79537 EAW79538 EAW79539 O75469 AB307701 BAH02292 AF061056 AAD05436 AF084644 AAC64557 AF084645 AAC64558 AJ009936 CAB55489 AJ009937 CAB55492 AK122990 BAG53837 AK223456 AK310789 AY091855 AAM26736 BC017304 AAH17304 HQ692837 ADZ17348 HQ709177 ADZ17384 NM_003889 NP_003880 NM_022002 NP_071285 NM_033013 NP_148934
Function	Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:12606758}.
Tissue Specificity	Expressed in liver, colon and small intestine.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PXR (G-11) - sc-48403 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PXR (H-11) - sc-48340 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PXR (N-16) - sc-9690 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PXR (H-160) - sc-25381 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PXR.1 (A-20) - sc-7737 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PXR.1 (N-19) - sc-9691 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PXR antibody - ab118336 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PXR antibody - ab85451 from Abcam Prices $378.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PXR antibody - ab109728 from Abcam Prices $376.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-PXR antibody - ab192579 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PXR antibody - ab81970 from Abcam Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-PXR antibody - ab66756 from Abcam Host Rabbit Clonality Polyclonal

Anti-PXR antibody [H0502] - ab41929 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone H0502

Anti-PXR antibody [H4417] - ab41930 from Abcam Prices $372.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone H4417

Anti-NR1I2 / PXR Antibody (aa18-32) - LS-C92290 from LifeSpan Bioscience Prices $485.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (Internal, AP) - LS-C245434 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (Internal, APC) - LS-C245435 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (Internal, Biotin) - LS-C245436 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (C-Terminus) - LS-C31660 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (Internal, FITC) - LS-C245437 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (aa91-140) - LS-C291461 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (Internal, Azide-free, HRP) - LS-C247782 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (N-Terminus) - LS-C40313 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (aa246-431, Biotin) - LS-C300197 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NR1I2 / PXR Antibody (aa205-390, Biotin) - LS-C300515 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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