| Gene Symbol |
NR1I2
|
| Entrez Gene |
8856
|
| Alt Symbol |
BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 1, group I, member 2
|
| Other Description |
nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PAR1|orphan nuclear receptor PXR|pregnane X nuclear receptor variant 2|pregnane X receptor|steroid and xenobiotic receptor
|
| Swissprots |
Q9UJ27 Q9UJ22 Q006P5 Q9UJ25 Q008C8 Q9UJ24 Q96AC7 O75469 Q9UJ26 Q9UNW4 Q9UJ23
|
| Accessions |
AAG23345 AAK38720 AAK38721 AAK38722 ABJ52965 ABJ52966 ABR09276 EAW79537 EAW79538 EAW79539 O75469 AB307701 BAH02292 AF061056 AAD05436 AF084644 AAC64557 AF084645 AAC64558 AJ009936 CAB55489 AJ009937 CAB55492 AK122990 BAG53837 AK223456 AK310789 AY091855 AAM26736 BC017304 AAH17304 HQ692837 ADZ17348 HQ709177 ADZ17384 NM_003889 NP_003880 NM_022002 NP_071285 NM_033013 NP_148934
|
| Function |
Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:12606758}.
|
| Tissue Specificity |
Expressed in liver, colon and small intestine.
|