NR1I2

Gene Symbol	NR1I2
Entrez Gene	8856
Alt Symbol	BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Species	Human
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group I, member 2
Other Description	nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PAR1|orphan nuclear receptor PXR|pregnane X nuclear receptor variant 2|pregnane X receptor|steroid and xenobiotic receptor
Swissprots	Q9UJ27 Q9UJ22 Q006P5 Q9UJ25 Q008C8 Q9UJ24 Q96AC7 O75469 Q9UJ26 Q9UNW4 Q9UJ23
Accessions	AAG23345 AAK38720 AAK38721 AAK38722 ABJ52965 ABJ52966 ABR09276 EAW79537 EAW79538 EAW79539 O75469 AB307701 BAH02292 AF061056 AAD05436 AF084644 AAC64557 AF084645 AAC64558 AJ009936 CAB55489 AJ009937 CAB55492 AK122990 BAG53837 AK223456 AK310789 AY091855 AAM26736 BC017304 AAH17304 HQ692837 ADZ17348 HQ709177 ADZ17384 NM_003889 NP_003880 NM_022002 NP_071285 NM_033013 NP_148934
Function	Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:12606758}.
Tissue Specificity	Expressed in liver, colon and small intestine.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PXR full length protein - ab82082 from Abcam Category Protein Source Baculovirus Species Human

Human PXR protein fragment - ab82046 from Abcam Category Protein Source E. coli Species Human

NR1I2 / PXR Antibody Blocking Peptide - LS-E14410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1I2 / PXR Antibody Blocking Peptide - LS-E12841 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1I2 / PXR Antibody Blocking Peptide - LS-E12842 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1I2 / PXR Antibody Blocking Peptide - LS-E9715 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NR1I2 / PXR Antibody Blocking Peptide - LS-E26983 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PXR/NR1I2 Protein - H00008856-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PXR/NR1I2 Protein - H00008856-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

NR1I2-Antibody-Center-Blocking-Peptide - BP8674c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PXR blocking peptide - GTX88474-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

PXR Peptide - AC21-1808-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NR1I2 - H00008856-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

NR1I2 - H00008856-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

NR1I2 - H00008856-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

NR1I2 - H00008856-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NR1I2 - H00008856-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NR1I2 Peptide - 46-930P from ProSci Category Peptide Species Human

PXR fusion protein - ag2086 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PXR fusion protein - Ag7991 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Recombinant PXR protein - 31144 from ActiveMotif Category Protein Prices $425.00 Sizes 5 µg Source Baculovirus Species Human

Recombinant Human NR1I2, Ligand Binding Domain - NR1I2-1896H from Creative Biomart Category Protein Source E. coli.

Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 2 - NR1I2-1095H from Creative Biomart Category Protein Source Baculovirus .

Recombinant Human NR1I2, His-tagged - NR1I2-31268TH from Creative Biomart Category Protein Source E. coli

Recombinant Human NR1I2 - NR1I2-31269TH from Creative Biomart Category Protein

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