NR1I2

Gene Symbol NR1I2
Entrez Gene 8856
Alt Symbol BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 1, group I, member 2
Other Description nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PAR1|orphan nuclear receptor PXR|pregnane X nuclear receptor variant 2|pregnane X receptor|steroid and xenobiotic receptor
Swissprots Q9UJ27 Q9UJ22 Q006P5 Q9UJ25 Q008C8 Q9UJ24 Q96AC7 O75469 Q9UJ26 Q9UNW4 Q9UJ23
Accessions AAG23345 AAK38720 AAK38721 AAK38722 ABJ52965 ABJ52966 ABR09276 EAW79537 EAW79538 EAW79539 O75469 AB307701 BAH02292 AF061056 AAD05436 AF084644 AAC64557 AF084645 AAC64558 AJ009936 CAB55489 AJ009937 CAB55492 AK122990 BAG53837 AK223456 AK310789 AY091855 AAM26736 BC017304 AAH17304 HQ692837 ADZ17348 HQ709177 ADZ17384 NM_003889 NP_003880 NM_022002 NP_071285 NM_033013 NP_148934
Function Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:12606758}.
Tissue Specificity Expressed in liver, colon and small intestine.

NR1I2-Over-expression-Lysate - LY10182a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag NR1I2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NR1I2 gene (Lane 2, Cat. #LY10182a).

NR1I2 293T Cell Transient Overexpression Lysate(Denatured) - H00008856-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

NR1I2 overexpression lysate - LY401282 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

NR1I2 293 Cell Lysate - 401178 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

PXR/NR1I2 Overexpression Lysate (Denatured) - H00008856-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

PXR/NR1I2 Overexpression Lysate (Native) - NBL1-13770 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: NR1I2 Overexpression Lysate (Adult Normal) [NBL1-13770] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NR1I2.

PXR (h): 293 Lysate - sc-158906 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

NR1I2 Over-expression Lysate Product - GWB-FF5153 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

PXR/NR1I2 Overexpression Lysate (Denatured) - H00008856-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human NR1I2 Knockdown Stable Cell Line - CSC-DC010590 from Creative biogene

Category Cell Line
Species Human
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