NR1I2
| Gene Symbol | NR1I2 |
|---|---|
| Entrez Gene | 8856 |
| Alt Symbol | BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 1, group I, member 2 |
| Other Description | nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PAR1|orphan nuclear receptor PXR|pregnane X nuclear receptor variant 2|pregnane X receptor|steroid and xenobiotic receptor |
| Swissprots | Q9UJ27 Q9UJ22 Q006P5 Q9UJ25 Q008C8 Q9UJ24 Q96AC7 O75469 Q9UJ26 Q9UNW4 Q9UJ23 |
| Accessions | AAG23345 AAK38720 AAK38721 AAK38722 ABJ52965 ABJ52966 ABR09276 EAW79537 EAW79538 EAW79539 O75469 AB307701 BAH02292 AF061056 AAD05436 AF084644 AAC64557 AF084645 AAC64558 AJ009936 CAB55489 AJ009937 CAB55492 AK122990 BAG53837 AK223456 AK310789 AY091855 AAM26736 BC017304 AAH17304 HQ692837 ADZ17348 HQ709177 ADZ17384 NM_003889 NP_003880 NM_022002 NP_071285 NM_033013 NP_148934 |
| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:9727070}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407, ECO:0000269|PubMed:12606758}. |
| Tissue Specificity | Expressed in liver, colon and small intestine. |
PXR CRISPR/Cas9 KO Plasmid (h) - sc-400824 from Santa Cruz Biotechnology
|
||||||||
PXR HDR Plasmid (h) - sc-400824-HDR from Santa Cruz Biotechnology
|
||||||||
PXR Double Nickase Plasmid (h) - sc-400824-NIC from Santa Cruz Biotechnology
|
||||||||
PXR Double Nickase Plasmid (h2) - sc-400824-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PXR CRISPR Activation Plasmid (h) - sc-400824-ACT from Santa Cruz Biotechnology
|
||||||||
PXR CRISPR Activation Plasmid (h2) - sc-400824-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PXR Lentiviral Activation Particles (h) - sc-400824-LAC from Santa Cruz Biotechnology
|
||||||||
PXR Lentiviral Activation Particles (h2) - sc-400824-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PXR siRNA (h) - sc-44057 from Santa Cruz Biotechnology
|
||||||||
PXR shRNA Plasmid (h) - sc-44057-SH from Santa Cruz Biotechnology
|
||||||||
PXR shRNA (h) Lentiviral Particles - sc-44057-V from Santa Cruz Biotechnology
|
||||||||
PXR/NR1I2 RNAi - H00008856-R03 from Novus Biologicals
|
||||||||
PXR/NR1I2 RNAi - H00008856-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU081471 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1280 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1280 from Sigma-Aldrich
|
||||||||
NR1I2 siRNA (Human) - CRH5848 from Cohesion Biosciences
|
||||||||
PXR/NR1I2 RNAi - H00008856-R02 from Novus Biologicals
|
||||||||
shRNA set against Human NR1I2 (NM_022002.2) - SHH354700 from Creative biogene
|
||||||||
shRNA set against Human NR1I2(NM_033013.2) - SHR020128 from Creative biogene
|
||||||||
shRNA set against Human NR1I2(NM_003889.3) - SHR020226 from Creative biogene
|
||||||||
shRNA set against Human NR1I2(NM_033013.2) - SHR020244 from Creative biogene
|
||||||||
shRNA set against Human NR1I2(NM_022002.2) - SHR020268 from Creative biogene
|
||||||||
Human NR1I2 siRNA - orb266350 from Biorbyt
|
||||||||
NR1I2 shRNA Plasmid (Human) - CHH5848 from Cohesion Biosciences
|