| Gene Symbol | SOCS4 |
|---|---|
| Entrez Gene | 122809 |
| Alt Symbol | SOCS7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of cytokine signaling 4 |
| Other Description | SH2 domain containing SOCS box protein|SOCS-4|SOCS-7|suppressor of cytokine signaling 7 |
| Swissprots | Q8WXH5 |
| Accessions | EAW80655 Q8WXH5 AF424815 AAL60517 AK056685 AK124083 BAG54001 AK126195 AK127299 BC060790 AAH60790 BX161418 CAD61893 BX648734 CD109883 CR933659 CAI45958 HQ448516 ADQ32995 XM_011536425 XP_011534727 XM_011536426 XP_011534728 NM_080867 NP_543143 NM_199421 NP_955453 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}. |
| Top Pathways | Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway |
suppressor of cytokine signaling 4, ELISA Kit - MBS9327041 from MyBioSource
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Human SOCS7 ELISA Kit - E036967 from Biobool
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anti-SOCS7 antibody - ARG64790 from Arigo Biolaboratories
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SOCS4 (Suppressor Of Cytokine Signaling 4), ELISA Kit - MBS7606586 from MyBioSource
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SOCS4 ELISA Kit (Human) (OKWB00191) - OKWB00191 from Aviva Systems Biology
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Human SOCS4 ELISA Kit (Sandwich ELISA) - LS-F31897 from LifeSpan Bioscience
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