SOCS4

Gene Symbol	SOCS4
Entrez Gene	122809
Alt Symbol	SOCS7
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 4
Other Description	SH2 domain containing SOCS box protein|SOCS-4|SOCS-7|suppressor of cytokine signaling 7
Swissprots	Q8WXH5
Accessions	EAW80655 Q8WXH5 AF424815 AAL60517 AK056685 AK124083 BAG54001 AK126195 AK127299 BC060790 AAH60790 BX161418 CAD61893 BX648734 CD109883 CR933659 CAI45958 HQ448516 ADQ32995 XM_011536425 XP_011534727 XM_011536426 XP_011534728 NM_080867 NP_543143 NM_199421 NP_955453
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}.
Top Pathways	Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SOCS4-cDNA-Clone - DC08192 from Abgent, a WuXi AppTec company Prices $594.00 Sizes 10 µg Species Human Accession BC060790

SOCS4 - MBS1269521 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC060790

Human SOCS4 cDNA clone(NM_080867.2) - CDFG007531 from Creative Biomart Species Human Accession NM_080867.2

Human SOCS4 cDNA clone(NM_199421.1) - CDFG013131 from Creative Biomart Species Human Accession NM_199421.1

Human SOCS4 ORF clone(NM_080867.2) - CDCL186258 from Creative Biomart Species Human Accession NM_080867.2

Human SOCS4 ORF Clone(NM_080867.2) - CDCR315351 from Creative Biomart Species Human Accession NM_080867.2

Human SOCS4 ORF Clone(NM_080867.2) - CDCR315352 from Creative Biomart Species Human Accession NM_080867.2

Human SOCS4 ORF Clone(NM_199421.1) - CDCR326818 from Creative Biomart Species Human Accession NM_199421.1

Human SOCS4 ORF Clone(NM_199421.1) - CDCR326819 from Creative Biomart Species Human Accession NM_199421.1

human SOCS4 ORF clone - CDCH084378 from Creative Biomart Species Human Accession NM_080867

human SOCS4 ORF clone - CDCH084379 from Creative Biomart Species Human Accession NM_080867

Human SOCS4 ORF Clone(NM_080867.2) - CDCL176641 from Creative Biomart Species Human Accession NM_080867.2

Human SOCS4 Gene cDNA clone plasmid - HG11316-M from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11316-ACG from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11316-NF from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11316-NM from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11316-CF from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11316-CM from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11316-NY from Sino Biological Species Human

Human SOCS4 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11316-M-N from Sino Biological Species Human Accession NM_080867.2

Human SOCS4 Gene ORF cDNA clone expression plasmid, C-His tag - HG11316-CH from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11316-ANG from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11316-ACR from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid - HG11316-UT from Sino Biological Species Human

Human SOCS4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11316-ANR from Sino Biological Species Human

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