| Gene Symbol |
SOCS4
|
| Entrez Gene |
122809
|
| Alt Symbol |
SOCS7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of cytokine signaling 4
|
| Other Description |
SH2 domain containing SOCS box protein|SOCS-4|SOCS-7|suppressor of cytokine signaling 7
|
| Swissprots |
Q8WXH5
|
| Accessions |
EAW80655 Q8WXH5 AF424815 AAL60517 AK056685 AK124083 BAG54001 AK126195 AK127299 BC060790 AAH60790 BX161418 CAD61893 BX648734 CD109883 CR933659 CAI45958 HQ448516 ADQ32995 XM_011536425 XP_011534727 XM_011536426 XP_011534728 NM_080867 NP_543143 NM_199421 NP_955453
|
| Function |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}.
|
| Top Pathways |
Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway
|
