SOCS4

Gene Symbol SOCS4
Entrez Gene 122809
Alt Symbol SOCS7
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 4
Other Description SH2 domain containing SOCS box protein|SOCS-4|SOCS-7|suppressor of cytokine signaling 7
Swissprots Q8WXH5
Accessions EAW80655 Q8WXH5 AF424815 AAL60517 AK056685 AK124083 BAG54001 AK126195 AK127299 BC060790 AAH60790 BX161418 CAD61893 BX648734 CD109883 CR933659 CAI45958 HQ448516 ADQ32995 XM_011536425 XP_011534727 XM_011536426 XP_011534728 NM_080867 NP_543143 NM_199421 NP_955453
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}.
Top Pathways Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway

SOCS-4 CRISPR/Cas9 KO Plasmid (h) - sc-406094 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 HDR Plasmid (h) - sc-406094-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 Double Nickase Plasmid (h) - sc-406094-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 Double Nickase Plasmid (h2) - sc-406094-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 CRISPR Activation Plasmid (h) - sc-406094-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 CRISPR Activation Plasmid (h2) - sc-406094-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 Lentiviral Activation Particles (h) - sc-406094-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 Lentiviral Activation Particles (h2) - sc-406094-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SOCS-4 siRNA (h) - sc-63050 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SOCS-4 shRNA Plasmid (h) - sc-63050-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SOCS-4 shRNA (h) Lentiviral Particles - sc-63050-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN20323 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20323 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SOCS4 siRNA (Human) - CRJ4713 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOCS4 - MBS8237065 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SOCS4 (NM_080867.2) - SHH414972 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SOCS4(NM_080867.2) - SHL024372 from Creative biogene

Category siRNA
Species Reactivities Human

Human SOCS4 siRNA - orb275214 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SOCS4 shRNA Plasmid (Human) - CHJ4713 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SOCS4 miRNA 3'UTR clone - MiUTR1H-09732 from Creative biogene

Species Reactivities Human
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