SOCS4

Gene Symbol SOCS4
Entrez Gene 122809
Alt Symbol SOCS7
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 4
Other Description SH2 domain containing SOCS box protein|SOCS-4|SOCS-7|suppressor of cytokine signaling 7
Swissprots Q8WXH5
Accessions EAW80655 Q8WXH5 AF424815 AAL60517 AK056685 AK124083 BAG54001 AK126195 AK127299 BC060790 AAH60790 BX161418 CAD61893 BX648734 CD109883 CR933659 CAI45958 HQ448516 ADQ32995 XM_011536425 XP_011534727 XM_011536426 XP_011534728 NM_080867 NP_543143 NM_199421 NP_955453
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}.
Top Pathways Jak-STAT signaling pathway, Insulin signaling pathway, Type II diabetes mellitus, Prolactin signaling pathway

SOCS-4 (C-17) - sc-68825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOCS-4 (C-17): sc-68825. Western blot analysis of SOCS-4 expression in non-transfected: sc-117752 (A) and human SOCS-4 transfected: sc-371694 (B) 293T whole cell lysates.

SOCS-4 (N-20) - sc-68827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOCS-4 (N-20): sc-68827. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing cytoplasmic and nuclear staining of glandular cells and myoepithelial cells.

SOCS-4 (S-19) - sc-68828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SOCS-4 (9J12) - sc-135566 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SOCS-4 (9J12): sc-135566. Western blot analysis of SOCS-4 expression in human SOCS-4 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-SOCS4 antibody - ab3694 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 antibody - ab170436 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SOCS4 antibody (ab170436) at 1/100 dilution + A2058 cell lysate at 35 µg

Anti-SOCS4 antibody - ab88545 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Immunofluorescence of ab88545 to SOCS4 on HeLa cells (antibody concentration 10 ug/ml)

Anti-SOCS4 antibody - ab13948 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 antibody - ab118530 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Adrenal tissue (formalin-fixed, paraffin-embedded) stained with ab118530 at 10 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SOCS4 antibody - ab97285 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SOCS4 antibody (ab97285) at 1/200 dilution + HeLa S3 whole cell lysate at 30 µg

Anti-SOCS4 antibody - ab57337 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57337 SOCS4 antibody at 1ug/ml.

Anti-SOCS4 Antibody (aa234-262, APC) - LS-C241106 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa234-262, Biotin) - LS-C241107 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa234-262, FITC) - LS-C241108 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa234-262, PE) - LS-C241109 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa223-253, AP) - LS-C241110 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa223-253, APC) - LS-C241111 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa223-253, Biotin) - LS-C241112 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa223-253, FITC) - LS-C241113 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa223-253, Azide-free, HRP) - LS-C248222 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa223-253, PE) - LS-C241115 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa234-262, Azide-free, HRP) - LS-C248223 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa223-253) - LS-C325269 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa234-262) - LS-C330171 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SOCS4 Antibody (aa224-253) - LS-C161382 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SOCS4 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The SOCS4 antibody detected the SOCS4 protein (arrow).
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