Gene Symbol | TNFAIP1 |
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Entrez Gene | 7126 |
Alt Symbol | B12, B61, BTBD34, EDP1, hBACURD2 |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor, alpha-induced protein 1 (endothelial) |
Other Description | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2|BTB/POZ domain-containing protein TNFAIP1 |
Swissprots | B7Z6M4 Q5TZQ1 Q13829 |
Accessions | AAL38649 EAW51077 Q13829 AK300584 BAH13310 AK312387 BAG35304 BC001643 AAH01643 BC001949 AAH01949 BC003694 BT020121 AAV38924 CR456819 CAG33100 DB093553 DQ892758 ABM83684 DQ896003 ABM86981 M80783 AAA58385 NM_021137 NP_066960 |
Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}. |
Subcellular Location | Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes. |
TNFα-IP 1 (A-15) - sc-82050 from Santa Cruz Biotechnology
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TNFα-IP 1 (C-19) - sc-82051 from Santa Cruz Biotechnology
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TNFα-IP 1 (N-16) - sc-82053 from Santa Cruz Biotechnology
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TNFα-IP 1 (H-64) - sc-366359 from Santa Cruz Biotechnology
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Anti-TNFAIP1 antibody - ab86934 from Abcam
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Anti-TNFAIP1 antibody - ab137202 from Abcam
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Anti-TNFAIP1 Antibody (N-Terminus) - LS-C122514 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (N-Terminus, Magnetic beads) - LS-C172100 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (N-Terminus, Sepharose) - LS-C172101 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa295-324, AP) - LS-C271834 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa295-324, APC) - LS-C271835 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa295-324, FITC) - LS-C271837 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa295-324, Biotin) - LS-C271836 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa295-324, Azide-free, HRP) - LS-C271838 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa71-120) - LS-C119031 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa295-324, PE) - LS-C271839 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa295-324) - LS-C330233 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa288-316) - LS-C162052 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa251-300) - LS-C205669 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (aa73-122) - LS-C200795 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (N-Terminus) - LS-C172099 from LifeSpan Bioscience
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Anti-TNFAIP1 Antibody (Ser122) - LS-C192036 from LifeSpan Bioscience
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TNFAIP1 Antibody - NBP1-88931 from Novus Biologicals
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TNFAIP1 Antibody - NBP1-88930 from Novus Biologicals
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TNFAIP1 Antibody - H00007126-A01 from Novus Biologicals
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