MAP1LC3B

Gene Symbol MAP1LC3B
Entrez Gene 81631
Alt Symbol ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a
Species Human
Gene Type protein-coding
Description microtubule-associated protein 1 light chain 3 beta
Other Description MAP1 light chain 3-like protein 2|MAP1A/MAP1B LC3 B|MAP1A/MAP1B light chain 3 B|autophagy-related ubiquitin-like modifier LC3 B|microtubule-associated proteins 1A/1B light chain 3B
Swissprots Q6NW02 Q9GZQ8
Accessions EAW95392 EAW95393 EAW95394 EAW95395 EAW95396 EAW95397 EAW95398 EAW95399 Q9GZQ8 AF087871 AAM10499 AF183417 AAG09686 AF303888 AAG23182 AK024571 AK025556 BAB15169 AK290956 BAF83645 AK310224 AK310335 AL834298 CAD38970 AM393561 CAL38438 BC018634 AAH18634 BC041874 AAH41874 BC045759 AAH45759 BC048009 BC067797 AAH67797 BG771621 DA577457 DB055844 DQ893152 ABM84078 DQ896448 ABM87447 JN663879 AEZ06292 NM_022818 NP_073729
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. {ECO:0000269|PubMed:20418806, ECO:0000269|PubMed:23209295, ECO:0000269|PubMed:24089205}.
Subcellular Location Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.
Tissue Specificity Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver. {ECO:0000269|PubMed:12740394}.

LC3A/B (D3U4C) XP ® Rabbit mAb (PE Conjugate) - 13611 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D3U4C
Flow cytometric analysis of HeLa cells, untreated (blue) or treated with chloroquine (50 µM, 16 hr) (green), using LC3A/B (D3U4C) XP ® Rabbit mAb (PE Conjugate).

LC3B (D11) XP ® Rabbit mAb (PE Conjugate) - 8899 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D11
Flow cytometric analysis of ACHN cells, untreated (blue) or chloroquine-treated (green), using LC3B (D11) XP ® Rabbit mAb (PE Conjugate).

LC3B (D11) XP ® Rabbit mAb (Biotinylated) - 12513 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D11
Western blot analysis of HeLa cell extracts, untreated (-) or chloroquine-treated (50 μM; +), using LC3B (D11) XP ® Rabbit mAb (Biotinylated).

LC3B (D11) XP ® Rabbit mAb - 3868 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D11
Western blot analysis of extracts from various cell lines, untreated (-) or treated overnight with chloroquine (50 μM) (+), using LC3B (D11) XP ® Rabbit mAb (upper) or LC3B Antibody #2775 (lower).

LC3B Antibody - 2775 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa cells, mock transfected or transfected with rat LC3B, and from HT-1080 and A20 cells, untreated or chloroquine-treated (50 μM, overnight), using LC3B Antibody.

MAP LC3α/β (F-14) - sc-16756 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MAP LC3α/β (G-4) - sc-398822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAP LC3α/β (G-4): sc-398822. Western blot analysis of MAPLC3α/β expression in IMR-32 whole cell lysate (A) and human brain tissue extract (B).

MAP LC3α/β (S-15) - sc-54237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MAP LC3α/β (S-15): sc-54237. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells.

MAP LC3β (G-9) - sc-376404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAP LC3β (G-9): sc-376404. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic and nuclear staining of glandular cells.

MAP LC3β (G-2) - sc-271625 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAP LC3β (G-2): sc-271625. Western blot analysis of MAP LC3β expression in IMR-32 whole cell lysate.

MAP LC3β (H-50) - sc-28266 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MAP LC3β (H-50): sc-28266. Western blot analysis of human recombinant MAP LC3β fusion protein.

MAP LC3β (N-20) - sc-16755 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MAP LC3β (N-20): sc-16755. Western blot analysis of MAP LC3β expression in non-transfected: sc-117752 (A) and human MAP LC3β transfected: sc-173201 (B) 293T whole cell lysates and mouse brain tissue extract (C).

Anti-LC3A/B antibody - ab128025 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-LC3A/B antibody (ab128025) at 1/1000 dilution + Mouse heart tissue cell lysate at 30 µgSecondaryHRP-conjugated Goat anti-rabbit IgG polyclonal at 1/4000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-LC3A/B antibody - ab62721 from Abcam

Prices $382.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-LC3A/B antibody (ab62721) at 0.5 µg/mlLanes 2 - 3 : Anti-LC3A/B antibody (ab62721) at 1 µg/mlLane 1 : Rat whole brain extractLane 2 : Rat whole brain extractLane 3 : Rat whole brain extract with immunizing peptideSecondaryGoat Anti-Rabbit IgG, Peroxidase conjugate developed using the ECL technique

Anti-LC3A/B antibody - ab173752 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-LC3A/B antibody (ab173752) at 1/50 dilution + Mouse lung lysate at 35 µg

Anti-LC3B antibody - ab51520 from Abcam

Prices $401.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LC3B antibody (ab51520) at 1/3000 dilutionLane 1 : treated U87-MG (human glioblastoma astrocytoma) lysates with Arsenic Trioxide at 0 µMLane 2 : treated U87-MG (human glioblastoma astrocytoma) lysates with Arsenic Trioxide at 2 µMLane 3 : treated U87-MG (human glioblastoma astrocytoma) lysates with Arsenic Trioxide at 4 µMLane 4 : treated U87-MG (human glioblastoma astrocytoma) lysates with Arsenic Trioxide at 8 µM

Anti-LC3B antibody [5H12] - ab129376 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5H12
ab129376 staining LC3B antigen by ELISA

Anti-LC3B antibody - Aminoterminal end - ab56115 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LC3B antibody - N-terminal - ab168831 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed and paraffin-embedded Human testis tissue labeling LC3B with ab168831 at 1/50.

Anti-MAP1LC3B / LC3B Antibody (N-Terminus) IHC-plus™ - LS-B10153 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-MAP1LC3B / LC3B antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10153 concentration 10 ug/ml.

Anti-MAP1LC3B / LC3B Antibody (N-Terminus) IHC-plus™ - LS-B9650 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
LC3B staining in glioblastoma multiforme tissues.

Anti-MAP1LC3B / LC3B Antibody (aa1-30) - LS-C165711 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent of U251 cells, using LC3 Antibody (APG8B). U251 cells(right) were treated with Chloroquine (50 mu M,16h). Antibody was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). DAPI was used to stain the cell nuclear (blue).

Anti-MAP1LC3B / LC3B Antibody (N-Terminus) - LS-C33334 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-MAP1LC3B / LC3B Antibody (N-Terminus) - LS-C46979 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAP1LC3B / LC3B Antibody (Internal) - LS-C71556 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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