DKK2

Gene Symbol DKK2
Entrez Gene 27123
Alt Symbol DKK-2
Species Human
Gene Type protein-coding
Description dickkopf WNT signaling pathway inhibitor 2
Other Description dickkopf 2 homolog|dickkopf homolog 2|dickkopf related protein-2|dickkopf-2|dickkopf-related protein 2|hDkk-2
Swissprots Q9UIU3 B2R6S7 A0AVE9 Q9UBU2
Accessions BAA87056 EAX06208 EAX06209 Q9UBU2 AB033208 BAA85465 AB033941 BAB20420 AF177395 AAF02675 AK309466 AK312695 BAG35574 AY358414 AAQ88780 BC075077 AAH75077 BC075078 AAH75078 BC126328 AAI26329 BC126330 AAI26331 HQ258135 ADR82889 NM_014421 NP_055236
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location Secreted.
Tissue Specificity Expressed in heart, brain, skeletal muscle and lung.
Top Pathways Wnt signaling pathway

DKK2 (N70) Antibody - 4689 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of COS cell extracts, untransfected or transiently transfected with a construct expressing DKK2, using DKK2 (N70) Antibody.

DKK2 (G44) Antibody - 4683 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, untransfected or transiently transfected with a construct expressing DKK2, using DKK2 (G44) Antibody.

Dkk-2 (H-140) - sc-25517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dkk-2 (H-140): sc-25517. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix, uterine tissue showing cytoplasmic and membrane staining of glandular and surface epithelial cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Dkk-2 (E-15) - sc-30786 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Dkk-2 (L-20) - sc-14953 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Dkk-2 (T-20) - sc-30787 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Dkk-2 (Q-23) - sc-130738 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Dkk-2 (Q-23): sc-130738. Western blot analysis of Dkk-2 expression in Jurkat whole cell lysate.

Anti-DKK2 antibody - ab21187 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab21187 (2µg/ml) western blot detection of DKK2 from Human Heart lysate (35µg protein in RIPA buffer). Primary incubation of 1 hour, detected by chemiluminescence

Anti-DKK2 antibody - ab95274 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-DKK2 antibody (ab95274) at 4 µg/mlLanes 2 - 4 : Anti-DKK2 antibody (ab95274) at 4 µg/ml (in 1X TBS/T with 5% nonfat milk, overnight at 4C.)Lane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysateLane 3 : 3T3 cell lysateLane 4 : Rat kidney tissue lysateSecondaryAnti-rabbit conjugated secondary antibody

Anti-DKK2 antibody - Aminoterminal end - ab38594 from Abcam

Prices $401.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DKK2 antibody - Aminoterminal end (ab38594) at 1/100 dilution + Jurkat cell lysate

Anti-DKK2 Antibody (aa31-62) IHC-plus™ - LS-B11830 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-DKK2 Antibody (Gly44) - LS-C64747 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (Asn70) - LS-C64748 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody - LS-C146958 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (N-Terminus, AP) - LS-C276786 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (aa245-259) - LS-C54723 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (2 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-DKK2 Antibody (N-Terminus, Biotin) - LS-C276788 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (N-Terminus, APC) - LS-C276787 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (N-Terminus, FITC) - LS-C276789 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (N-Terminus, PE) - LS-C276791 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (C-Terminus, AP) - LS-C276792 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (N-Terminus, Azide-free, HRP) - LS-C276790 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (C-Terminus, APC) - LS-C276793 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (C-Terminus, Biotin) - LS-C276794 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK2 Antibody (C-Terminus, Azide-free, HRP) - LS-C276797 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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