DKK2

Gene Symbol	DKK2
Entrez Gene	27123
Alt Symbol	DKK-2
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 2
Other Description	dickkopf 2 homolog|dickkopf homolog 2|dickkopf related protein-2|dickkopf-2|dickkopf-related protein 2|hDkk-2
Swissprots	Q9UIU3 B2R6S7 A0AVE9 Q9UBU2
Accessions	BAA87056 EAX06208 EAX06209 Q9UBU2 AB033208 BAA85465 AB033941 BAB20420 AF177395 AAF02675 AK309466 AK312695 BAG35574 AY358414 AAQ88780 BC075077 AAH75077 BC075078 AAH75078 BC126328 AAI26329 BC126330 AAI26331 HQ258135 ADR82889 NM_014421 NP_055236
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in heart, brain, skeletal muscle and lung.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DKK2 full length protein - ab190999 from Abcam Category Protein Prices $110.00, $308.00 Sizes 2 µg, 10 µg Source CHO Species Human

Human DKK2 full length protein - ab131710 from Abcam Category Protein Source E. coli Species Human

Human DKK2 peptide - ab45461 from Abcam Category Peptide Species Human

DKK2 Antibody Blocking Peptide - LS-E3795 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK2 Antibody Blocking Peptide - LS-E3794 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK2 Antibody Blocking Peptide - LS-E25317 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK2 Antibody Blocking Peptide - LS-E19868 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Dkk-2 Protein - NBP2-23000 from Novus Biologicals Category Protein Prices $299.00 Sizes 20 µg Source E.coli Species Human

Dkk-2 Peptide - P0530 from Novus Biologicals Category Peptide Species Human

Dkk-2 Peptide - P0529 from Novus Biologicals Category Peptide Species Human

DKK2-Antibody-C-term-Blocking-Peptide - BP1522b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKK2-Antibody-N-term-Blocking-Peptide - BP1522a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKK2 blocking peptide - GTX41187-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Recombinant Human Dkk-2 - 6628-DK-010 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Met1-Ile259

Recombinant Human Dkk-2, CF - 6628-DK-010/CF from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Met1-Ile259

Human Dkk-2 protein - orb180247 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human DKK2 protein - orb168235 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Source E.coli

Human DKK2 protein - orb244953 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Goat anti DKK2 antibody Immunizing peptide - orb16789 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

DKK2 Blocking Peptide - 33R-10552 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

DKK2 Blocking Peptide - 33R-10919 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

DKK2 protein (His tag) - 80R-2444 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

Human DKK2 Protein - abx066332 from Abbexa Category Protein Source E.coli Species Human

DKK2 Peptide - AC21-0145-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Dickkopf-2 (DKK2) - AR31144PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source CHO cells Species Human

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