DKK2

Gene Symbol DKK2
Entrez Gene 27123
Alt Symbol DKK-2
Species Human
Gene Type protein-coding
Description dickkopf WNT signaling pathway inhibitor 2
Other Description dickkopf 2 homolog|dickkopf homolog 2|dickkopf related protein-2|dickkopf-2|dickkopf-related protein 2|hDkk-2
Swissprots Q9UIU3 B2R6S7 A0AVE9 Q9UBU2
Accessions BAA87056 EAX06208 EAX06209 Q9UBU2 AB033208 BAA85465 AB033941 BAB20420 AF177395 AAF02675 AK309466 AK312695 BAG35574 AY358414 AAQ88780 BC075077 AAH75077 BC075078 AAH75078 BC126328 AAI26329 BC126330 AAI26331 HQ258135 ADR82889 NM_014421 NP_055236
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location Secreted.
Tissue Specificity Expressed in heart, brain, skeletal muscle and lung.
Top Pathways Wnt signaling pathway

Dkk-2 CRISPR/Cas9 KO Plasmid (h) - sc-403725 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 HDR Plasmid (h) - sc-403725-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 Double Nickase Plasmid (h) - sc-403725-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 Double Nickase Plasmid (h2) - sc-403725-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 CRISPR Activation Plasmid (h) - sc-403725-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 CRISPR Activation Plasmid (h2) - sc-403725-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 Lentiviral Activation Particles (h) - sc-403725-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 Lentiviral Activation Particles (h2) - sc-403725-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dkk-2 siRNA (h) - sc-37084 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dkk-2 shRNA Plasmid (h) - sc-37084-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dkk-2 shRNA (h) Lentiviral Particles - sc-37084-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU051371 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7275 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7275 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11125 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11125

DKK2 siRNA (Human) - CRH8977 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DKK2 - MBS8213517 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DKK2 (NM_014421.2) - SHH278353 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DKK2(NM_014421.2) - SHH006155 from Creative biogene

Category siRNA
Species Reactivities Human

Human DKK2 siRNA - orb269479 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DKK2 shRNA Plasmid (Human) - CHH8977 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DKK2 miRNA 3'UTR clone - MiUTR1H-02858 from Creative biogene

Species Reactivities Human
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