Gene Symbol | DKK2 |
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Entrez Gene | 27123 |
Alt Symbol | DKK-2 |
Species | Human |
Gene Type | protein-coding |
Description | dickkopf WNT signaling pathway inhibitor 2 |
Other Description | dickkopf 2 homolog|dickkopf homolog 2|dickkopf related protein-2|dickkopf-2|dickkopf-related protein 2|hDkk-2 |
Swissprots | Q9UIU3 B2R6S7 A0AVE9 Q9UBU2 |
Accessions | BAA87056 EAX06208 EAX06209 Q9UBU2 AB033208 BAA85465 AB033941 BAB20420 AF177395 AAF02675 AK309466 AK312695 BAG35574 AY358414 AAQ88780 BC075077 AAH75077 BC075078 AAH75078 BC126328 AAI26329 BC126330 AAI26331 HQ258135 ADR82889 NM_014421 NP_055236 |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in heart, brain, skeletal muscle and lung. |
Top Pathways | Wnt signaling pathway |
Dkk-2 CRISPR/Cas9 KO Plasmid (h) - sc-403725 from Santa Cruz Biotechnology
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Dkk-2 HDR Plasmid (h) - sc-403725-HDR from Santa Cruz Biotechnology
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Dkk-2 Double Nickase Plasmid (h) - sc-403725-NIC from Santa Cruz Biotechnology
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Dkk-2 Double Nickase Plasmid (h2) - sc-403725-NIC-2 from Santa Cruz Biotechnology
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Dkk-2 CRISPR Activation Plasmid (h) - sc-403725-ACT from Santa Cruz Biotechnology
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Dkk-2 CRISPR Activation Plasmid (h2) - sc-403725-ACT-2 from Santa Cruz Biotechnology
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Dkk-2 Lentiviral Activation Particles (h) - sc-403725-LAC from Santa Cruz Biotechnology
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Dkk-2 Lentiviral Activation Particles (h2) - sc-403725-LAC-2 from Santa Cruz Biotechnology
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Dkk-2 siRNA (h) - sc-37084 from Santa Cruz Biotechnology
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Dkk-2 shRNA Plasmid (h) - sc-37084-SH from Santa Cruz Biotechnology
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Dkk-2 shRNA (h) Lentiviral Particles - sc-37084-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU051371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7275 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7275 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11125 from Sigma-Aldrich
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DKK2 siRNA (Human) - CRH8977 from Cohesion Biosciences
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DKK2 - MBS8213517 from MyBioSource
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shRNA set against Human DKK2 (NM_014421.2) - SHH278353 from Creative biogene
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shRNA set against Human DKK2(NM_014421.2) - SHH006155 from Creative biogene
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Human DKK2 siRNA - orb269479 from Biorbyt
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DKK2 shRNA Plasmid (Human) - CHH8977 from Cohesion Biosciences
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DKK2 miRNA 3'UTR clone - MiUTR1H-02858 from Creative biogene
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