| Gene Symbol |
DKK2
|
| Entrez Gene |
27123
|
| Alt Symbol |
DKK-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dickkopf WNT signaling pathway inhibitor 2
|
| Other Description |
dickkopf 2 homolog|dickkopf homolog 2|dickkopf related protein-2|dickkopf-2|dickkopf-related protein 2|hDkk-2
|
| Swissprots |
Q9UIU3 B2R6S7 A0AVE9 Q9UBU2
|
| Accessions |
BAA87056 EAX06208 EAX06209 Q9UBU2 AB033208 BAA85465 AB033941 BAB20420 AF177395 AAF02675 AK309466 AK312695 BAG35574 AY358414 AAQ88780 BC075077 AAH75077 BC075078 AAH75078 BC126328 AAI26329 BC126330 AAI26331 HQ258135 ADR82889 NM_014421 NP_055236
|
| Function |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed in heart, brain, skeletal muscle and lung.
|
| Top Pathways |
Wnt signaling pathway
|
![Western Blot: DKK2 Overexpression Lysate (Adult Normal) [NBP2-04343] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DKK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9884_DKK2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04343-img0001.jpg)