DKK2

Gene Symbol	DKK2
Entrez Gene	27123
Alt Symbol	DKK-2
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 2
Other Description	dickkopf 2 homolog|dickkopf homolog 2|dickkopf related protein-2|dickkopf-2|dickkopf-related protein 2|hDkk-2
Swissprots	Q9UIU3 B2R6S7 A0AVE9 Q9UBU2
Accessions	BAA87056 EAX06208 EAX06209 Q9UBU2 AB033208 BAA85465 AB033941 BAB20420 AF177395 AAF02675 AK309466 AK312695 BAG35574 AY358414 AAQ88780 BC075077 AAH75077 BC075078 AAH75078 BC126328 AAI26329 BC126330 AAI26331 HQ258135 ADR82889 NM_014421 NP_055236
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in heart, brain, skeletal muscle and lung.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-DKK2-cDNA-Clone - DC14404 from Abgent, a WuXi AppTec company Prices $349.65 Sizes 10 µg Species Human Accession BC126328

DKK2 - MBS1278812 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC126328

Human DKK2 cDNA clone(NM_014421.2) - CDFH005124 from Creative Biomart Species Human Accession NM_014421.2

Human DKK2 ORF clone(NM_014421.2) - CDCL183923 from Creative Biomart Species Human Accession NM_014421.2

Human DKK2 ORF Clone(NM_014421.2) - CDCL161138 from Creative Biomart Species Human Accession NM_014421.2

Human DKK2 ORF Clone(NM_014421.2) - CDCR297542 from Creative Biomart Species Human Accession NM_014421.2

Human DKK2 ORF Clone(NM_014421.2) - CDCR297543 from Creative Biomart Species Human Accession NM_014421.2

Human DKK2 Gene ORF cDNA clone in cloning vector - HG11262-M from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11262-CH from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11262-NH from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11262-CY from Sino Biological Species Human

Human DKK2 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11262-M-N from Sino Biological Species Human Accession NM_014421.2

Human DKK2 Gene ORF cDNA clone expression plasmid - HG11262-UT from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11262-ACR from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11262-ACG from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11262-NF from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11262-NM from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11262-CF from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11262-CM from Sino Biological Species Human

Human DKK2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11262-NY from Sino Biological Species Human

Human DKK2 ORF clone(NM_014421.2) - CDCL183923 from Creative biogene Species Human

Human DKK2 ORF Clone (BC126328) - CDCS413619 from Creative biogene Species Human Accession Q9UBU2

Human DKK2 cDNA Clone(NM_014421.2) - CDFH005124 from Creative biogene Species Human

Human Dickkopf 2 Gene - orb91738 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Search more