| Gene Symbol |
TIGIT
|
| Entrez Gene |
201633
|
| Alt Symbol |
VSIG9, VSTM3, WUCAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
T cell immunoreceptor with Ig and ITIM domains
|
| Other Description |
T-cell immunoreceptor with Ig and ITIM domains|V-set and immunoglobulin domain containing 9|V-set and immunoglobulin domain-containing protein 9|V-set and transmembrane domain containing 3|V-set and transmembrane domain-containing protein 3|Washington University cell adhesion molecule
|
| Swissprots |
Q8N877 Q495A1 Q6MZS2 Q495A3 Q5JPD8
|
| Accessions |
EAW79602 Q495A1 AK097192 BAC04973 AL833175 CAI46183 BC101288 AAI01289 BC101289 AAI01290 BC101290 AAI01291 BC101291 AAI01292 BX640915 CAE45956 EU675310 ACD74757 XM_011512538 XP_011510840 XM_011512539 XP_011510841 NM_173799 NP_776160
|
| Function |
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.
|
| Tissue Specificity |
Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269|PubMed:19011627}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|