TIGIT

Gene Symbol	TIGIT
Entrez Gene	201633
Alt Symbol	VSIG9, VSTM3, WUCAM
Species	Human
Gene Type	protein-coding
Description	T cell immunoreceptor with Ig and ITIM domains
Other Description	T-cell immunoreceptor with Ig and ITIM domains|V-set and immunoglobulin domain containing 9|V-set and immunoglobulin domain-containing protein 9|V-set and transmembrane domain containing 3|V-set and transmembrane domain-containing protein 3|Washington University cell adhesion molecule
Swissprots	Q8N877 Q495A1 Q6MZS2 Q495A3 Q5JPD8
Accessions	EAW79602 Q495A1 AK097192 BAC04973 AL833175 CAI46183 BC101288 AAI01289 BC101289 AAI01290 BC101290 AAI01291 BC101291 AAI01292 BX640915 CAE45956 EU675310 ACD74757 XM_011512538 XP_011510840 XM_011512539 XP_011510841 NM_173799 NP_776160
Function	Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.
Tissue Specificity	Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269|PubMed:19011627}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TIGIT Blocking Peptide - LS-E346 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TIGIT-Antibody-C-term-Blocking-Peptide - BP10616b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human TIGIT Fc Chimera, CF - 7898-TG-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human TIGIT His tag protein - orb83411 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Human TIGIT Protein - abx069243 from Abbexa Category Protein Source E.coli Species Human

T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT), Human - 20-9545 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

VSTM3 Recombinant Protein - 96-722 from ProSci Category Protein Prices $500.00 Sizes 50 µg Source HEK293 cells Species Human

TIGIT fusion protein - Ag16158 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TIGIT fusion protein - ag17031 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human TIGIT, His tagged - TIGIT-2347H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human TIGIT, Fc-tagged - TIGIT-105H from Creative Biomart Category Protein Source CHO Cells Species Human

Recombinant Human TIGIT, GST-tagged - TIGIT-3232H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human TIGIT, Fc-tagged - TIGIT-107H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human TIGIT, His-tagged - TIGIT-106H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human TIGIT, Fc Chimera - TIGIT-356H from Creative Biomart Category Protein Source CHO cells Species Human

Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) - RPN056Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) - RPN056Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) - RPN056Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Human TIGIT / VSTM3 Protein (His Tag) - 10917-H08H-10 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 10 µg, 20 µg Source Human Cells Species Human

Human TIGIT Protein, Fc Tag - TIT-H5254 from ACROBiosystems Category Protein Source Recombinant Human TIGIT /VSIG9/VSTM3 Protein,C-Fc Tag (rh TIGIT / VSIG9 / VSTM3 Fc Chimera) Met 22 - Pro 141 (Accession # AAI01290) was produced in human 293 cells (HEK293) at ACROBiosystems. Species Human

Recombinant T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) - RPN056Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human T-cell immunoreceptor with Ig and ITIM domains(TIGIT) - CSB-YP675446HU CSB-EP675446HU CSB-BP675446HU CSB-MP675446HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human TIGIT Fc Chimera Protein, CF - 7898-TG from R&D Systems Category Protein Prices $339.00, $4,250.00 Sizes 50 µg, 1 mg Source Chinese Hamster Ovary cell line, CHO-derived Human TIGIT (Met22-Pro141) Accession # AAI01289 IEGRMD Human IgG 1 (Pro100-Lys330) N-terminus C-terminus Species Human

T-Cell Immunoreceptor With Ig And ITIM Domains Protein (TIGIT) - RPU143958 from Biomatik Category Protein Prices $231.00, $462.00, $693.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

TIGIT (C-term DDK/His tag) - TP700214 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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