TIGIT

Gene Symbol	TIGIT
Entrez Gene	201633
Alt Symbol	VSIG9, VSTM3, WUCAM
Species	Human
Gene Type	protein-coding
Description	T cell immunoreceptor with Ig and ITIM domains
Other Description	T-cell immunoreceptor with Ig and ITIM domains|V-set and immunoglobulin domain containing 9|V-set and immunoglobulin domain-containing protein 9|V-set and transmembrane domain containing 3|V-set and transmembrane domain-containing protein 3|Washington University cell adhesion molecule
Swissprots	Q8N877 Q495A1 Q6MZS2 Q495A3 Q5JPD8
Accessions	EAW79602 Q495A1 AK097192 BAC04973 AL833175 CAI46183 BC101288 AAI01289 BC101289 AAI01290 BC101290 AAI01291 BC101291 AAI01292 BX640915 CAE45956 EU675310 ACD74757 XM_011512538 XP_011510840 XM_011512539 XP_011510841 NM_173799 NP_776160
Function	Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.
Tissue Specificity	Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269|PubMed:19011627}.
Top Pathways	Cell adhesion molecules (CAMs)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TIGIT gene - orb91373 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

TIGIT - MBS1268734 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC101289

human TIGIT ORF clone - CDCH091094 from Creative Biomart Species Human Accession NM_173799

human TIGIT ORF clone - CDCH091095 from Creative Biomart Species Human Accession NM_173799

human TIGIT ORF clone - CDCH091096 from Creative Biomart Species Human Accession NM_173799

human TIGIT ORF clone - CDCH091097 from Creative Biomart Species Human Accession NM_173799

Human TIGIT/VSTM3 Gene ORF cDNA clone in cloning vector - HG10917-M from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid - HG10917-UT from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10917-ACG from Sino Biological Species Human

Human TIGIT / VSTM3 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10917-M-F from Sino Biological Species Human Accession NM_173799.2

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10917-NF from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10917-NM from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10917-CY from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10917-CF from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10917-CM from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, N-His tag - HG10917-NH from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10917-NY from Sino Biological Species Human

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, C-His tag - HG10917-CH from Sino Biological Species Human

Human TIGIT (NP_776160) VersaClone cDNA - RDC1417 from R&D Systems Prices $199.00 Sizes 10 µg Species Human

human TIGIT ORF clone (NM_173799.3) - CDCH091094 from Creative biogene Species Human

Human TIGIT ORF Clone (BC101289) - CDCS417459 from Creative biogene Species Human Accession Q495A1

Cynomolgus Monkey TIGIT (XP_005548157) VersaClone cDNA - RDC1568 from R&D Systems Prices $199.00 Sizes 10 µg Species Monkey

Human TIGIT/VSTM3 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10917-ACR from Sino Biological Species Human

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