TIGIT

Gene Symbol TIGIT
Entrez Gene 201633
Alt Symbol VSIG9, VSTM3, WUCAM
Species Human
Gene Type protein-coding
Description T cell immunoreceptor with Ig and ITIM domains
Other Description T-cell immunoreceptor with Ig and ITIM domains|V-set and immunoglobulin domain containing 9|V-set and immunoglobulin domain-containing protein 9|V-set and transmembrane domain containing 3|V-set and transmembrane domain-containing protein 3|Washington University cell adhesion molecule
Swissprots Q8N877 Q495A1 Q6MZS2 Q495A3 Q5JPD8
Accessions EAW79602 Q495A1 AK097192 BAC04973 AL833175 CAI46183 BC101288 AAI01289 BC101289 AAI01290 BC101290 AAI01291 BC101291 AAI01292 BX640915 CAE45956 EU675310 ACD74757 XM_011512538 XP_011510840 XM_011512539 XP_011510841 NM_173799 NP_776160
Function Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.
Tissue Specificity Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). {ECO:0000269|PubMed:19011627}.
Top Pathways Cell adhesion molecules (CAMs)

VSTM3 CRISPR/Cas9 KO Plasmid (h) - sc-404147 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 HDR Plasmid (h) - sc-404147-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 Double Nickase Plasmid (h) - sc-404147-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 Double Nickase Plasmid (h2) - sc-404147-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 CRISPR Activation Plasmid (h) - sc-404147-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 CRISPR Activation Plasmid (h2) - sc-404147-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 Lentiviral Activation Particles (h) - sc-404147-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 Lentiviral Activation Particles (h2) - sc-404147-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VSTM3 siRNA (h) - sc-78458 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VSTM3 shRNA Plasmid (h) - sc-78458-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VSTM3 shRNA (h) Lentiviral Particles - sc-78458-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN21353 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21353 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09168 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09168

TIGIT siRNA (Human) - CRJ6302 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TIGIT - MBS8213051 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TIGIT (NM_173799.3) - SHH427336 from Creative biogene

Category siRNA
Species Reactivities Human

Human TIGIT siRNA - orb276803 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TIGIT shRNA Plasmid (Human) - CHJ6302 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TIGIT miRNA 3'UTR clone - MiUTR4H-TG08979 from Creative biogene

Species Reactivities Human
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