ARC

Gene Symbol	ARC
Entrez Gene	23237
Alt Symbol	Arg3.1
Species	Human
Gene Type	protein-coding
Description	activity-regulated cytoskeleton-associated protein
Other Description	ARC/ARG3.1|activity-regulated gene 3.1 protein homolog
Swissprots	Q9UJW6 Q9Y469 Q7LC44
Accessions	AAG33705 CBX47608 EAW82320 EAW82321 Q7LC44 AF193421 AAF07185 AI096899 BC012321 AAH12321 BC075802 AAH75802 BI752734 D87468 BAA19667 DQ893666 ABM84592 DQ895780 ABM86706 NM_015193 NP_056008
Function	Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Top Pathways	Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ARC-Over-expression-Lysate - LY13702a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ARC 293T Cell Transient Overexpression Lysate(Denatured) - H00023237-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ARC overexpression lysate - LY414716 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ARC/ARG3.1 Overexpression Lysate (Denatured) - H00023237-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Arc (h): 293T Lysate - sc-117312 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Arc (h2): 293T Lysate - sc-170557 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Arc (h3): 293T Lysate - sc-170140 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ARC/ARG3.1 Overexpression Lysate (Native) - NBP2-10294 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human ARC Knockdown Stable Cell Line - CSC-DC000826 from Creative biogene Category Cell Line Species Human

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