ARC

Gene Symbol	ARC
Entrez Gene	23237
Alt Symbol	Arg3.1
Species	Human
Gene Type	protein-coding
Description	activity-regulated cytoskeleton-associated protein
Other Description	ARC/ARG3.1|activity-regulated gene 3.1 protein homolog
Swissprots	Q9UJW6 Q9Y469 Q7LC44
Accessions	AAG33705 CBX47608 EAW82320 EAW82321 Q7LC44 AF193421 AAF07185 AI096899 BC012321 AAH12321 BC075802 AAH75802 BI752734 D87468 BAA19667 DQ893666 ABM84592 DQ895780 ABM86706 NM_015193 NP_056008
Function	Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Top Pathways	Amphetamine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-ARC-cDNA-Clone - DC03364 from Abgent, a WuXi AppTec company Prices $534.60 Sizes 10 µg Species Human Accession BC012321

ARC - MBS1271340 from MyBioSource Species Human Accession BC012321

Human ARC ORF Clone(NM_015193.4) - CDCL154212 from Creative Biomart Species Human Accession NM_015193.4

Human ARC Gene ORF cDNA clone in cloning vector - HG12204-G from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12204-NM from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12204-CF from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12204-ACG from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12204-CM from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, C-HA tag - HG12204-CY from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG12204-ANG from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, N-His tag - HG12204-NH from Sino Biological Species Human

Human ARC Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG12204-NY from Sino Biological Species Human Accession BC012321

Human ARC Gene ORF cDNA clone expression plasmid - HG12204-UT from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12204-ACR from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG12204-ANR from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, C-His tag - HG12204-CH from Sino Biological Species Human

Human ARC Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12204-NF from Sino Biological Species Human

Human ARC ORF Clone (BC012321) - CDCS413899 from Creative biogene Species Human Accession Q7LC44

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