ARC

Gene Symbol ARC
Entrez Gene 23237
Alt Symbol Arg3.1
Species Human
Gene Type protein-coding
Description activity-regulated cytoskeleton-associated protein
Other Description ARC/ARG3.1|activity-regulated gene 3.1 protein homolog
Swissprots Q9UJW6 Q9Y469 Q7LC44
Accessions AAG33705 CBX47608 EAW82320 EAW82321 Q7LC44 AF193421 AAF07185 AI096899 BC012321 AAH12321 BC075802 AAH75802 BI752734 D87468 BAA19667 DQ893666 ABM84592 DQ895780 ABM86706 NM_015193 NP_056008
Function Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Top Pathways Amphetamine addiction

Arc CRISPR/Cas9 KO Plasmid (h) - sc-400231 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc HDR Plasmid (h) - sc-400231-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc Double Nickase Plasmid (h) - sc-400231-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc Double Nickase Plasmid (h2) - sc-400231-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc CRISPR Activation Plasmid (h) - sc-400231-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc CRISPR Activation Plasmid (h2) - sc-400231-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc Lentiviral Activation Particles (h) - sc-400231-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc Lentiviral Activation Particles (h2) - sc-400231-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Arc siRNA (h) - sc-29721 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Arc shRNA Plasmid (h) - sc-29721-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Arc shRNA (h) Lentiviral Particles - sc-29721-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN3384 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3384 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06611 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06611

ARC siRNA (Human) - CRH8112 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARC - MBS8208430 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ARC (NM_015193.4) - SHH239026 from Creative biogene

Category siRNA
Species Reactivities Human

Human ARC siRNA - orb268614 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARC shRNA Plasmid (Human) - CHH8112 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ARC miRNA 3'UTR clone - MiUTR3H-12453 from Creative biogene

Species Reactivities Human
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