ARC

Gene Symbol ARC
Entrez Gene 23237
Alt Symbol Arg3.1
Species Human
Gene Type protein-coding
Description activity-regulated cytoskeleton-associated protein
Other Description ARC/ARG3.1|activity-regulated gene 3.1 protein homolog
Swissprots Q9UJW6 Q9Y469 Q7LC44
Accessions AAG33705 CBX47608 EAW82320 EAW82321 Q7LC44 AF193421 AAF07185 AI096899 BC012321 AAH12321 BC075802 AAH75802 BI752734 D87468 BAA19667 DQ893666 ABM84592 DQ895780 ABM86706 NM_015193 NP_056008
Function Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000250}. Endosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q63053, ECO:0000250|UniProtKB:Q9WV31}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:21834987}.
Top Pathways Amphetamine addiction

Arc (C-7) - sc-17839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Arc (C-7): sc-17839. Western blot analysis of Arc expression in U-87 MG (A) and SH-SY5Y (B) whole cell lysates and mouse brain tissue extract (C).

Arc (H-300) - sc-15325 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Arc (H-300): sc-15325. Western blot analysis of Arc expression in PC-12 whole cell lysate (A) and mouse brain extract (B).

Arc (H-6) - sc-365736 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Arc (H-6): sc-365736. Western blot analysis of Arc expression in non-transfected: sc-117752 (A) and human Arc transfected: sc-170140 (B) 293T whole cell lysates.

Arc (A-7) - sc-166461 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Arc (A-7): sc-166461. Western blot analysis of Arc expression in non-transfected: sc-117752 (A) and human Arc transfected: sc-117312 (B) 293T whole cell lysates.

Arc (E-7) - sc-55475 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Arc (E-7): sc-55475. Western blot analysis of Arc expression in U-87 MG whole cell lysate.

Arc (E-19) - sc-6382 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Arc (E-19): sc-6382. Western blot analysis of Arc expression in non-transfected: sc-117752 (A) and human Arc transfected: sc-170557 (B) 293T whole cell lysates.

Arc (K-14) - sc-33947 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Arc (K-14): sc-33947. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic and membrane staining of glandular cells.

Arc (R-20) - sc-6381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Arc (R-20): sc-6381. Western blot analysis of Arc expression in non-transfected: sc-117752 (A) and human Arc transfected: sc-117312 (B) 293T whole cell lysates.

Arc (40) - sc-136278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Arc (40): sc-136278. Western blot analysis of Arc expression in rat cerebrum tissue extract.

Anti-Arc antibody - ab167305 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Arc antibody (ab167305) at 1 µg/mlLane 1 : Arc transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-Arc antibody - ab118929 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Arc antibody (ab118929) at 1 µg/ml + Mouse brain lysate at 10 µg

Anti-Arg 3.1 antibody - ab62142 from Abcam

Host Sheep
Clonality Polyclonal

Anti-Arg 3.1 antibody - ab203056 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
A549 cells probed with ab203056 at 1:100 for 60 minutes at room temperature followed by Goat Anti-Rabbit IgG (H L) Alexa Fluor 488 Conjugated Secondary.

Anti-Arg 3.1 antibody - ab23382 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Arg 3.1 antibody (ab23382) at 1 µg/ml (with 3% milk block)Lane 1 : Forebrain (Mouse) Tissue LysateLane 2 : Rat Cortex Tissue LysateLane 3 : Hippocampus (Mouse) Tissue Lysate Lane 4 : Rat Hippocampus Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Arg 3.1 antibody - ab64120 from Abcam

Host Rabbit
Clonality Polyclonal
IHC image of ab64120 staining in human normal hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab64120, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-ARC / Arg3.1 Antibody (C-Terminus) - LS-C69242 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ARC / Arg3.1 Antibody - LS-C93850 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-ARC / Arg3.1 Antibody - LS-C93907 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-ARC / Arg3.1 Antibody (C-Terminus) - LS-C69243 from LifeSpan Bioscience

Prices $415.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-ARC / Arg3.1 Antibody (aa36-66, APC) - LS-C251605 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARC / Arg3.1 Antibody (aa36-66, Biotin) - LS-C251606 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARC / Arg3.1 Antibody (N-Terminus) - LS-C110353 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ARC antibody LS-C110353 Western blot of HeLa lysate.

Anti-ARC / Arg3.1 Antibody (aa36-66, FITC) - LS-C251607 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ARC / Arg3.1 Antibody (aa101-150) - LS-C145798 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ARC antibody LS-C145798 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-ARC / Arg3.1 Antibody - LS-C137193 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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