CSK

Gene Symbol	CSK
Entrez Gene	1445
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	c-src tyrosine kinase
Other Description	C-Src kinase|protein-tyrosine kinase CYL|tyrosine-protein kinase CSK
Swissprots	Q2M3N2 Q6FGZ6 P41240
Accessions	AAY57329 CAB58562 EAW99311 EAW99312 P41240 AB451288 BAG70102 AB451420 BAG70234 AK127672 BAG54548 AK223626 BAD97346 AK290531 BAF83220 AK297694 BAG60052 AK298245 BAG60511 AK309344 AK310136 AK312669 BAG35551 AW575209 AY007162 BC104847 AAI04848 BC104875 AAI04876 BC106073 AAI06074 CR541960 CAG46758 X59932 CAA42556 X60114 CAA42713 XM_005254165 XP_005254222 NM_001127190 NP_001120662 NM_004383 NP_004374
Function	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.
Tissue Specificity	Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.
Top Pathways	Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® Csk Kinase Assay Kit - 7802 from Cell Signaling Technology Category Assay Kit

Phosphotyrosine CSK / Tyrosine-protein Kinase CSK ELISA Kit - RAB0939 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Tyrosine-protein kinase CSK (CSK), Human, ELISA Kit - CSB-EL006056HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Tyrosine-protein kinase CSK (CSK), Human, ELISA Kit - E01T0608 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Tyrosine-protein kinase CSK, CSK, Human, ELISA Kit - E11982h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

CSK (Human) IP-WB Antibody Pair - H00001445-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CSK Colorimetric Cell-Based ELISA Kit - CB5177 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Csk (Phospho-Ser364) Colorimetric Cell-Based ELISA Kit - CBP1107 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

c-src tyrosine kinase, ELISA Kit - MBS912053 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CSK is typically less than 4.68 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 18.75 pg/ml -1200 pg/ml.

Tyrosine protein kinase CSK (CSK), ELISA Kit - MBS7248720 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7204103 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7221007 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7251241 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7252035 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7224392 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7237456 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7212113 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7233170 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7243728 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Tyrosine-protein kinase CSK (CSK), ELISA Kit - MBS7239123 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Tyrosine-protein kinase CSK(CSK) ELISA kit - CSB-EL006056HU from Cusabio Category ELISA Kit Sensitivity 4.68 pg/ml Range 18.75 pg/ml-1200 pg/ml

CSK ELISA Kit - DEIA-XYA485 from Creative Diagnostics Category ELISA Kit

Csk (Phospho-Ser364) ELISA Kit - DEIA-XYA486 from Creative Diagnostics Category ELISA Kit

CSK - EKH2736 from Nordic BioSite Sensitivity 0.469ng/ml Range 0.78-50ng/ml

CSK ELISA Kit (Human) : 96 Wells (OKEH02196) - OKEH02196 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 0.43 ng/mL Range 0.78 - 50 ng/mL

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