CSK

Gene Symbol	CSK
Entrez Gene	1445
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	c-src tyrosine kinase
Other Description	C-Src kinase|protein-tyrosine kinase CYL|tyrosine-protein kinase CSK
Swissprots	Q2M3N2 Q6FGZ6 P41240
Accessions	AAY57329 CAB58562 EAW99311 EAW99312 P41240 AB451288 BAG70102 AB451420 BAG70234 AK127672 BAG54548 AK223626 BAD97346 AK290531 BAF83220 AK297694 BAG60052 AK298245 BAG60511 AK309344 AK310136 AK312669 BAG35551 AW575209 AY007162 BC104847 AAI04848 BC104875 AAI04876 BC106073 AAI06074 CR541960 CAG46758 X59932 CAA42556 X60114 CAA42713 XM_005254165 XP_005254222 NM_001127190 NP_001120662 NM_004383 NP_004374
Function	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.
Tissue Specificity	Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.
Top Pathways	Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CSK-Over-expression-Lysate - LY10161a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CSK 293 Cell Lysate - 401273 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CSK Overexpression Lysate (Native) - NBL1-09525 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Csk (h): 293T Lysate - sc-111742 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CSK Over-expression Lysate Product - GWB-415B1A from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human CSK / C-Src kinase Insect Cell Lysate (WB positive control) - 10740-H09BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

CSK Overexpression Lysate (Native) - NBP2-09427 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CSK Overexpression Lysate (Denatured) - H00001445-T03 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human CSK Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175002 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human CSK Knockdown Stable Cell Line - CSC-DC003711 from Creative biogene Category Cell Line Species Human

CSK KO Cell Lysate-HEK293T - CLKO-0704 from Creative biogene Category Cell Lysate

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