CSK

Gene Symbol	CSK
Entrez Gene	1445
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	c-src tyrosine kinase
Other Description	C-Src kinase|protein-tyrosine kinase CYL|tyrosine-protein kinase CSK
Swissprots	Q2M3N2 Q6FGZ6 P41240
Accessions	AAY57329 CAB58562 EAW99311 EAW99312 P41240 AB451288 BAG70102 AB451420 BAG70234 AK127672 BAG54548 AK223626 BAD97346 AK290531 BAF83220 AK297694 BAG60052 AK298245 BAG60511 AK309344 AK310136 AK312669 BAG35551 AW575209 AY007162 BC104847 AAI04848 BC104875 AAI04876 BC106073 AAI06074 CR541960 CAG46758 X59932 CAA42556 X60114 CAA42713 XM_005254165 XP_005254222 NM_001127190 NP_001120662 NM_004383 NP_004374
Function	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.
Tissue Specificity	Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.
Top Pathways	Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CSK full length protein - ab60764 from Abcam Category Protein Prices $286.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human CSK full length protein - ab42617 from Abcam Category Protein Prices $321.00 Sizes 10 µg Source Baculovirus Species Human

Human CSK full length protein - ab187439 from Abcam Category Protein Source E. coli Species Human

Human CSK full length protein - ab82187 from Abcam Category Protein Source E. coli Species Human

Human CSK peptide - ab19039 from Abcam Category Peptide Species Human

CSK Recombinant Protein - H00001445-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CSK Partial Recombinant Protein - H00001445-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CSK Recombinant Protein - P4206 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

CSK Recombinant Protein - P3855 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

CSK Recombinant Protein - P3854 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

CSK Recombinant Protein - P4673 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant CSK Protein - NBP1-99474 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

CSK Peptide - P2745 from Novus Biologicals Category Peptide Species Human

CSK-Antibody-N-term-Blocking-peptide - BP13748a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CSK-Antibody-C-term-Blocking-Peptide - BP7700b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CSK (Active) recombinant protein - GTX65061 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

CSK blocking peptide - GTX89784-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Human CSK GST tag protein - orb84093 from Biorbyt Category Protein Prices $323.00, $434.00 Sizes 20 μg, 50 μg Source Insect Species Human

CSK Blocking Peptide - 33R-8387 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CSK protein - 30R-2837 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

CSK protein (His tag) - 80R-3977 from Fitzgerald Category Protein Prices $295.00 Sizes 50 µg Source E.coli

CSK (phospho-Ser364) Blocking Peptide - abx062473 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Zebrafish

CSK Blocking Peptide - abx062083 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey

CSK Peptide - AC21-0053-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CSK (1-450, His-tag) - AR51662PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 250 µg Source E. coli Species Human

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