CSK

Gene Symbol CSK
Entrez Gene 1445
Alt Symbol -
Species Human
Gene Type protein-coding
Description c-src tyrosine kinase
Other Description C-Src kinase|protein-tyrosine kinase CYL|tyrosine-protein kinase CSK
Swissprots Q2M3N2 Q6FGZ6 P41240
Accessions AAY57329 CAB58562 EAW99311 EAW99312 P41240 AB451288 BAG70102 AB451420 BAG70234 AK127672 BAG54548 AK223626 BAD97346 AK290531 BAF83220 AK297694 BAG60052 AK298245 BAG60511 AK309344 AK310136 AK312669 BAG35551 AW575209 AY007162 BC104847 AAI04848 BC104875 AAI04876 BC106073 AAI06074 CR541960 CAG46758 X59932 CAA42556 X60114 CAA42713 XM_005254165 XP_005254222 NM_001127190 NP_001120662 NM_004383 NP_004374
Function Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.
Tissue Specificity Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.
Top Pathways Epithelial cell signaling in Helicobacter pylori infection

Csk (C74C1) Rabbit mAb - 4980 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C74C1
Western blot analysis of extracts from various cell lines using Csk (C74C1) Rabbit mAb.

Csk Antibody - 4965 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Csk (H-75) - sc-13074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Csk (H-75): sc-13074. Western blot analysis of Csk expression in non-transfected 293T: sc-117752 (A), human Csk transfected 293T: sc-111742 (B) and Jurkat (C) whole cell lysates.

Csk (E-3) - sc-166560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Csk (E-3): sc-166560. Western blot analysis of Csk expression in non-transfected: sc-117752 (A) and mouse Csk transfected: sc-119481 (B) 293T whole cell lysates.

Csk (C-20) - sc-286 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Csk (C-20): sc-286. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human spleen (A) and immunofluorescence staining of methanol-fixed Jurkat cells (B) showing cytoplasmic localization.

Csk (CSK-04) - sc-51580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Csk (CSK-04): sc-51580. Western blot analysis of Csk expression in BC3H1 whole cell lysate.

Csk (B-7) - sc-166513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Csk (B-7): sc-166513. Western blot analysis of Csk expression in non-transfected: sc-117752 (A) and mouse Csk transfected: sc-119481 (B) 293T whole cell lysates.

Csk (N-16) - sc-9897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Csk (N-16): sc-9897. Western blot analysis of Csk expression in non-transfected: sc-117752 (A) and human Csk transfected: sc-111742 (B) 293T whole cell lysates.

Anti-CSK (phospho S364) antibody - ab61782 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CSK (phospho S364) antibody (ab61782) at 1/500 dilutionLane 1 : extracts from HeLa cells, treated with PMA (125ng/ml, 30mins) with no immunizing peptideLane 2 : extracts from HeLa cells, treated with PMA (125ng/ml, 30mins) with immunizing peptide

Anti-CSK antibody - ab61756 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human breast carcinoma tissue stained with ab61756 at 1/50 dilution, with and without the immunising peptide.

Anti-CSK antibody - ab54684 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
CSK antibody (ab54684) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human colon.

Anti-CSK antibody - ab70065 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CSK antibody (ab70065) at 1/500 dilutionLane 1 : Jurkat cell extractLane 2 : Jurkat cell extract with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-CSK antibody [2B4-C6-A10] - ab176470 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2B4-C6-A10
All lanes : Anti-CSK antibody [2B4-C6-A10] (ab176470) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : C6 cell lysate

Anti-CSK antibody [5F3] - ab105930 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5F3
All lanes : Anti-CSK antibody [5F3] (ab105930) at 1/500 dilutionLane 1 : NIH/3T3 cell lysate.Lane 2 : Hela cell lysate.Lane 3 : COS7 cell lysate.Lane 4 : Jurkat cell lysate.Lane 5 : Raw246.7 cell lysate.Lane 6 : A549 cell lysate.Lane 7 : HL-60 cell lysate.Lane 8 : PC-12 cell lysate.

Anti-CSK antibody [CSK-04] - ab14996 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CSK-04
Ab14996 staining human normal skin tissue. Staining is localised to cytoplasm.Left panel: with primary antibody at 1 ug/ml. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 antigen retrieval buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 minutes and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-CSK antibody [EPR6771] - ab125005 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6771
All lanes : Anti-CSK antibody [EPR6771] (ab125005) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : Ramos cell lysateLane 3 : RAW 264.7 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

CSK Antibody (3A3) - H00001445-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A3

CSK Antibody - NB100-808 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

CSK Antibody (5F3) - NBP2-37651 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5F3
Western Blot: CSK Antibody (5F3) [NBP2-37651] - Western blot analysis using CSK mouse mAb against NIH/3T3 (1),Hela (2),COS7 (3), Jurkat (4), Raw246.7 (5), A549 (6), HL-60 (7) and PC-12 (8) cell lysate.

CSK Antibody - NBP1-89521 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CSK Antibody [NBP1-89521] - Lane 1: Mouse liver tissue lysate Lane 2: Rat liver tissue lysate

CSK Antibody - NBP1-19572 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CSK Antibody [NBP1-19572] Extracts from HepG2 cells.

CSK Antibody - NBP1-19457 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CSK Antibody [NBP1-19457] - extracts from Raw264.7 cells.

CSK Antibody (CSK-04) - NB500-344 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone CSK-04
Immunocytochemistry/Immunofluorescence: CSK Antibody (CSK-04) [NB500-344] - Staining of Csk in human HeLa cell line using anti-Csk (CSK-04; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).

CSK Antibody - H00001445-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: CSK Antibody [H00001445-D01P] - Analysis of CSK expression in transfected 293T cell line by CSK polyclonal antibody.Lane 1: CSK transfected lysate(50.70 KDa).Lane 2: Non-transfected lysate.

CSK Antibody - H00001445-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Search more