Gene Symbol | CSK |
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Entrez Gene | 1445 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | c-src tyrosine kinase |
Other Description | C-Src kinase|protein-tyrosine kinase CYL|tyrosine-protein kinase CSK |
Swissprots | Q2M3N2 Q6FGZ6 P41240 |
Accessions | AAY57329 CAB58562 EAW99311 EAW99312 P41240 AB451288 BAG70102 AB451420 BAG70234 AK127672 BAG54548 AK223626 BAD97346 AK290531 BAF83220 AK297694 BAG60052 AK298245 BAG60511 AK309344 AK310136 AK312669 BAG35551 AW575209 AY007162 BC104847 AAI04848 BC104875 AAI04876 BC106073 AAI06074 CR541960 CAG46758 X59932 CAA42556 X60114 CAA42713 XM_005254165 XP_005254222 NM_001127190 NP_001120662 NM_004383 NP_004374 |
Function | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}. |
Tissue Specificity | Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}. |
Top Pathways | Epithelial cell signaling in Helicobacter pylori infection |
Csk (C74C1) Rabbit mAb - 4980 from Cell Signaling Technology
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Csk Antibody - 4965 from Cell Signaling Technology
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Csk (H-75) - sc-13074 from Santa Cruz Biotechnology
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Csk (E-3) - sc-166560 from Santa Cruz Biotechnology
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Csk (C-20) - sc-286 from Santa Cruz Biotechnology
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Csk (CSK-04) - sc-51580 from Santa Cruz Biotechnology
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Csk (B-7) - sc-166513 from Santa Cruz Biotechnology
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Csk (N-16) - sc-9897 from Santa Cruz Biotechnology
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Anti-CSK (phospho S364) antibody - ab61782 from Abcam
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Anti-CSK antibody - ab61756 from Abcam
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Anti-CSK antibody - ab54684 from Abcam
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Anti-CSK antibody - ab70065 from Abcam
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Anti-CSK antibody [2B4-C6-A10] - ab176470 from Abcam
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Anti-CSK antibody [5F3] - ab105930 from Abcam
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Anti-CSK antibody [CSK-04] - ab14996 from Abcam
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Anti-CSK antibody [EPR6771] - ab125005 from Abcam
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CSK Antibody (3A3) - H00001445-M01 from Novus Biologicals
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CSK Antibody - NB100-808 from Novus Biologicals
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CSK Antibody (5F3) - NBP2-37651 from Novus Biologicals
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CSK Antibody - NBP1-89521 from Novus Biologicals
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CSK Antibody - NBP1-19572 from Novus Biologicals
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CSK Antibody - NBP1-19457 from Novus Biologicals
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CSK Antibody (CSK-04) - NB500-344 from Novus Biologicals
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CSK Antibody - H00001445-D01P from Novus Biologicals
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CSK Antibody - H00001445-A01 from Novus Biologicals
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