CSK
| Gene Symbol | CSK |
|---|---|
| Entrez Gene | 1445 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | c-src tyrosine kinase |
| Other Description | C-Src kinase|protein-tyrosine kinase CYL|tyrosine-protein kinase CSK |
| Swissprots | Q2M3N2 Q6FGZ6 P41240 |
| Accessions | AAY57329 CAB58562 EAW99311 EAW99312 P41240 AB451288 BAG70102 AB451420 BAG70234 AK127672 BAG54548 AK223626 BAD97346 AK290531 BAF83220 AK297694 BAG60052 AK298245 BAG60511 AK309344 AK310136 AK312669 BAG35551 AW575209 AY007162 BC104847 AAI04848 BC104875 AAI04876 BC106073 AAI06074 CR541960 CAG46758 X59932 CAA42556 X60114 CAA42713 XM_005254165 XP_005254222 NM_001127190 NP_001120662 NM_004383 NP_004374 |
| Function | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}. |
| Tissue Specificity | Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}. |
| Top Pathways | Epithelial cell signaling in Helicobacter pylori infection |
Csk CRISPR/Cas9 KO Plasmid (h) - sc-400992 from Santa Cruz Biotechnology
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Csk HDR Plasmid (h) - sc-400992-HDR from Santa Cruz Biotechnology
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Csk Double Nickase Plasmid (h) - sc-400992-NIC from Santa Cruz Biotechnology
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Csk Double Nickase Plasmid (h2) - sc-400992-NIC-2 from Santa Cruz Biotechnology
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Csk CRISPR Activation Plasmid (h) - sc-400992-ACT from Santa Cruz Biotechnology
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Csk CRISPR Activation Plasmid (h2) - sc-400992-ACT-2 from Santa Cruz Biotechnology
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Csk Lentiviral Activation Particles (h) - sc-400992-LAC from Santa Cruz Biotechnology
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Csk Lentiviral Activation Particles (h2) - sc-400992-LAC-2 from Santa Cruz Biotechnology
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Csk siRNA (h) - sc-39161 from Santa Cruz Biotechnology
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Csk shRNA Plasmid (h) - sc-39161-SH from Santa Cruz Biotechnology
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Csk shRNA (h) Lentiviral Particles - sc-39161-V from Santa Cruz Biotechnology
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CSK RNAi - H00001445-R01V from Novus Biologicals
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MISSION® esiRNA - EHU156801 from Sigma-Aldrich
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MISSION® siRNA - SIHK0502 from Sigma-Aldrich
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MISSION® siRNA - SIHK0501 from Sigma-Aldrich
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MISSION® siRNA - SIHK0499 from Sigma-Aldrich
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MISSION® siRNA - SIHK0500 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6638 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6638 from Sigma-Aldrich
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CSK siRNA (Human) - CRH1019 from Cohesion Biosciences
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CSK RNAi - H00001445-R02 from Novus Biologicals
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CSK - MBS8221959 from MyBioSource
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shRNA set against Human CSK (NM_004383.2) - SHH270337 from Creative biogene
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Human CSK siRNA - orb261521 from Biorbyt
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CSK shRNA Plasmid (Human) - CHH1019 from Cohesion Biosciences
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