CSK

Gene Symbol	CSK
Entrez Gene	1445
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	c-src tyrosine kinase
Other Description	C-Src kinase|protein-tyrosine kinase CYL|tyrosine-protein kinase CSK
Swissprots	Q2M3N2 Q6FGZ6 P41240
Accessions	AAY57329 CAB58562 EAW99311 EAW99312 P41240 AB451288 BAG70102 AB451420 BAG70234 AK127672 BAG54548 AK223626 BAD97346 AK290531 BAF83220 AK297694 BAG60052 AK298245 BAG60511 AK309344 AK310136 AK312669 BAG35551 AW575209 AY007162 BC104847 AAI04848 BC104875 AAI04876 BC106073 AAI06074 CR541960 CAG46758 X59932 CAA42556 X60114 CAA42713 XM_005254165 XP_005254222 NM_001127190 NP_001120662 NM_004383 NP_004374
Function	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
Subcellular Location	Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.
Tissue Specificity	Expressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.
Top Pathways	Epithelial cell signaling in Helicobacter pylori infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CSK cDNA clone(NM_001127190.1) - CDFH004342 from Creative Biomart Species Human Accession NM_001127190.1

Human CSK ORF clone(NM_001127190.1) - CDCL183742 from Creative Biomart Species Human Accession NM_001127190.1

Human CSK ORF Clone(NM_004383.2) - CDCL159896 from Creative Biomart Species Human Accession NM_004383.2

Human CSK ORF clone(NM_004383.2) - CDCH384240 from Creative Biomart Species Human Accession NM_004383.2

Human CSK ORF Clone(NM_001127190.1) - CDCR348504 from Creative Biomart Species Human Accession NM_001127190.1

Human CSK ORF Clone(NM_001127190.1) - CDCR348505 from Creative Biomart Species Human Accession NM_001127190.1

Human C-Src Kinase / CSK Gene ORF cDNA clone in cloning vector - HG10740-M from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10740-ACG from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10740-CM from Sino Biological Species Human

Human CSK Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10740-M-N from Sino Biological Species Human Accession NM_001127190.1

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, N-HA tag - HG10740-NY from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10740-ANG from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, C-His tag - HG10740-CH from Sino Biological Species Human

Human CSK Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-tagged - HG10740-M-F from Sino Biological Species Human Accession NM_001127190.1

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10740-ACR from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10740-ANR from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid - HG10740-UT from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10740-NF from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, N-His tag - HG10740-NH from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10740-NM from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10740-CF from Sino Biological Species Human

Human C-Src Kinase / CSK Gene ORF cDNA clone expression plasmid, C-HA tag - HG10740-CY from Sino Biological Species Human

Human CSK ORF clone(NM_004383.2) - CDCH384240 from Creative biogene Species Human

Human CSK ORF clone(NM_001127190.1) - CDCL183742 from Creative biogene Species Human

Human CSK cDNA Clone(NM_001127190.1) - CDFH004342 from Creative biogene Species Human

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