HDAC8

Gene Symbol HDAC8
Entrez Gene 55869
Alt Symbol CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species Human
Gene Type protein-coding
Description histone deacetylase 8
Other Description histone deacetylase-like 1
Swissprots Q9BY41 Q9NYH4 A6ND61 A6NJR3 B4DKN0 Q9NP76 B4DV22 Q86VC8 A6ND12 A6NET3 A8MQ62
Accessions EAW71821 EAW71822 EAW71823 EAW71824 Q9BY41 AF212246 AAK14930 AF230097 AAF73076 AF245664 AAF73428 AI651236 AI916593 AJ277724 CAB90213 AK054936 AK074326 AK294903 BAG57992 AK296641 BAG59242 AK298767 BAG60909 AK300895 BAG62534 AY429539 BC050433 AAH50433 BF514915 BP229332 BQ189619 BQ632790 DC352390 EU446822 ABZ92351 EU832800 ACE87811 GQ129378 ACT64512 XM_011530986 XP_011529288 XM_011530987 XP_011529289 XM_011530988 XP_011529290 XR_938402 NM_001166418 NP_001159890 NM_001166419 NP_001159891 NM_001166420 NP_001159892 NM_001166422 NP_001159894 NM_001166448 NP_001159920 NM_018486 NP_060956 NR_051952
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:10922473, ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:22885700}.
Subcellular Location Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Tissue Specificity Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. {ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}.
Top Pathways Viral carcinogenesis, Alcoholism

HDAC8 (B-4) - sc-365620 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC8 (B-4): sc-365620. Western blot analysis of HDAC8 expression in K-562 nuclear extract.

HDAC8 (E-5) - sc-17778 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC8 (E-5): sc-17778. Western blot analysis of HDAC8 expression in K-562 nuclear extract.

HDAC8 (F-9) - sc-374180 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HDAC8 (F-9): sc-374180. Western blot analysis of HDAC8 expression in MOLT-4 whole cell lysate.

HDAC8 (H-145) - sc-11405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HDAC8 (H-145): sc-11405. Western blot analysis of HDAC8 expression in TF-1 whole cell lysate.

HDAC8 (N-20) - sc-11544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of HDAC8 expression in MOLT-4 whole cell lysate (A) and K-562 nuclear extract (B). Antibodies tested include HDAC8 (N-20): sc-11544 (A) and HDAC8 (E-5): sc-17778 (B).

HDAC8 (HDAC8-48) - sc-56687 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
HDAC8 (HDAC8-48): sc-56687. Western blot analysis of HDAC8 expression in non-transfected: sc-117752 (A) and human HDAC8 transfected: sc-177327 (B) 293T whole cell lysates.

p-HDAC8 (Ser 39) - sc-101693 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-HDAC8 (Ser 39): sc-101693. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear staining.

Anti-HDAC8 (phospho S39) antibody - ab131516 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol-fixed HeLa cells labelling HDAC8 with ab131516 at 1/100 dilution.

Anti-HDAC8 (phospho S39) antibody - ab195057 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol-fixed HeLa cells labeling HDAC8 with ab195057 at a 1/100 dilution.

Anti-HDAC8 (phospho S39) antibody - ab38514 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab38514 at a 1:50 dilution staining HDAC8 in Human lung carcinoma tissue using Immunohistochemistry, Paraffin Embedded Tissue. Left image : untreated. Right image : treated with phosphopeptide at 1µg/ml.

Anti-HDAC8 (phospho S39) antibody - ab195953 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC8 (phospho S39) antibody (ab195953) at 1/500 dilutionLane 1 : NIH 3T3 whole cell lysate with antigen-specific peptideLane 2 : NIH 3T3 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-HDAC8 antibody - ab18968 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC8 antibody (ab18968)Lane 1 : human jurkat cell lysateLane 2 : human jurkat cell lysate

Anti-HDAC8 antibody - ab137474 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HDAC8 antibody (ab137474) at 1/1000 dilution + 293T whole cell lysate at 30 µg

Anti-HDAC8 antibody - ab23658 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC8 antibody (ab23658) at 1 µg/mlLane 1 : HeLa Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG H&L (HRP) Pre-Adsorbed at 1/10000 dilutionPerformed under reducing conditions.

Anti-HDAC8 antibody - ab126886 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HDAC8 antibody (ab126886) at 5 µg/mlLane 1 : Recombinant Human HDAC8 Protein at 0.03 µgLane 2 : Recombinant Human HDAC8 Protein at 0.06 µgLane 3 : Recombinant Human HDAC8 Protein at 0.12 µgLane 4 : Recombinant Human HDAC8 Protein at 0.25 µg

Anti-HDAC8 antibody [EPR10338(2)] - ab187139 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10338(2)
All lanes : Anti-HDAC8 antibody [EPR10338(2)] (ab187139) at 1/50000 dilutionLane 1 : K562 cell lysateLane 2 : Molt4 cell lysateLane 3 : HeLa cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-HDAC8 antibody [EPR17926] - ab186374 from Abcam

Prices $99.00
Sizes 10 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17926
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HeLa (Human epithelial cells from cervix adenocarcinoma) cells labeling HDAC8 with ab186374 at 1/100 dilution, followed by Goat anti-rabbit IgG (Alexa Fluor® 488) (ab150077) secondary antibody at 1/400 dilution (green). Confocal image showing nuclear and weak cytoplasmic staining on HeLa cell line. The nuclear counter stain is DAPI (blue). Tubulin is detected with ab7291 (anti-Tubulin mouse mAb) at 1/500 dilution and ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution (red).The negative controls are as follows:-ve control 1: ab186374 at 1/500 dilution followed by ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution.-ve control 2: ab7291 (anti-Tubulin mouse mAb) at 1/500 dilution followed by ab150077 (Alexa Fluor®488 Goat Anti-Rabbit IgG H&L) at 1/400 dilution.

Anti-HDAC8 antibody [HDAC8-48] - ab12176 from Abcam

Prices $372.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone HDAC8-48

Anti-HDAC8 antibody - N-terminal - ab190954 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Paraffin-embedded Human lung cancer tissue labeling HDAC8 with ab190954 at 1 µg/ml.

Anti-HDAC8 Antibody (aa18-33) - LS-C312748 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HDAC8 antibody. IHC(P): Human Lung Cancer Tissue.

Anti-HDAC8 Antibody (C-Terminus) IHC-plus™ - LS-B967 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-HDAC8 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B967 concentration 5 ug/ml.

Anti-HDAC8 Antibody (aa305-377) - LS-C7418 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HDAC8 Antibody (phospho-Ser39) - LS-C123691 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-HDAC8 Antibody - LS-C123692 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-HDAC8 Antibody - LS-C123756 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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