HDAC8

Gene Symbol	HDAC8
Entrez Gene	55869
Alt Symbol	CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 8
Other Description	histone deacetylase-like 1
Swissprots	Q9BY41 Q9NYH4 A6ND61 A6NJR3 B4DKN0 Q9NP76 B4DV22 Q86VC8 A6ND12 A6NET3 A8MQ62
Accessions	EAW71821 EAW71822 EAW71823 EAW71824 Q9BY41 AF212246 AAK14930 AF230097 AAF73076 AF245664 AAF73428 AI651236 AI916593 AJ277724 CAB90213 AK054936 AK074326 AK294903 BAG57992 AK296641 BAG59242 AK298767 BAG60909 AK300895 BAG62534 AY429539 BC050433 AAH50433 BF514915 BP229332 BQ189619 BQ632790 DC352390 EU446822 ABZ92351 EU832800 ACE87811 GQ129378 ACT64512 XM_011530986 XP_011529288 XM_011530987 XP_011529289 XM_011530988 XP_011529290 XR_938402 NM_001166418 NP_001159890 NM_001166419 NP_001159891 NM_001166420 NP_001159892 NM_001166422 NP_001159894 NM_001166448 NP_001159920 NM_018486 NP_060956 NR_051952
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. {ECO:0000269\|PubMed:10748112, ECO:0000269\|PubMed:10922473, ECO:0000269\|PubMed:10926844, ECO:0000269\|PubMed:14701748, ECO:0000269\|PubMed:22885700}.
Subcellular Location	Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Tissue Specificity	Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. {ECO:0000269\|PubMed:10926844, ECO:0000269\|PubMed:14701748, ECO:0000269\|PubMed:15772115, ECO:0000269\|PubMed:16538051}.
Top Pathways	Viral carcinogenesis, Alcoholism

Human-HDAC8-cDNA-Clone - DC07798 from Abgent, a WuXi AppTec company

Prices	$508.95
Sizes	10 µg
Species	Human
Accession	BC050433

HDAC8 - MBS1268134 from MyBioSource

Prices	$175.00
Sizes	10ug plasmid + 200ul glycerol stock
Species	Human
Accession	BC050433

Human HDAC8 cDNA clone(NM_001166418.1) - CDFH008365 from Creative Biomart

Species	Human
Accession	NM_001166418.1

Human HDAC8 cDNA clone(NM_001166420.1) - CDFH008366 from Creative Biomart

Species	Human
Accession	NM_001166420.1

Human HDAC8 cDNA clone(NM_001166419.1) - CDFH008367 from Creative Biomart

Species	Human
Accession	NM_001166419.1

Human HDAC8 cDNA clone(NM_001166422.1) - CDFH008368 from Creative Biomart

Species	Human
Accession	NM_001166422.1

Human HDAC8 cDNA clone(NM_001166448.1) - CDFH008369 from Creative Biomart

Species	Human
Accession	NM_001166448.1

Human HDAC8 ORF Clone(NM_018486.2) - CDCL165858 from Creative Biomart

Species	Human
Accession	NM_018486.2

Human HDAC8 ORF Clone(NM_001166418.1) - CDCR355361 from Creative Biomart

Species	Human
Accession	NM_001166418.1

Human HDAC8 ORF Clone(NM_001166419.1) - CDCR355362 from Creative Biomart

Species	Human
Accession	NM_001166419.1

Human HDAC8 ORF Clone(NM_001166419.1) - CDCR355363 from Creative Biomart

Species	Human
Accession	NM_001166419.1

Human HDAC8 ORF Clone(NM_001166420.1) - CDCR355364 from Creative Biomart

Species	Human
Accession	NM_001166420.1

Human HDAC8 ORF Clone(NM_001166420.1) - CDCR355365 from Creative Biomart

Species	Human
Accession	NM_001166420.1

Human HDAC8 ORF Clone(NM_001166422.1) - CDCR355366 from Creative Biomart

Species	Human
Accession	NM_001166422.1

Human HDAC8 ORF Clone(NM_001166418.1) - CDCR355367 from Creative Biomart

Species	Human
Accession	NM_001166418.1

Human HDAC8 ORF Clone(NM_001166422.1) - CDCR355368 from Creative Biomart

Species	Human
Accession	NM_001166422.1

Human HDAC8 ORF Clone(NM_001166448.1) - CDCR355381 from Creative Biomart

Species	Human
Accession	NM_001166448.1

Human HDAC8 ORF Clone(NM_001166448.1) - CDCR355387 from Creative Biomart

Species	Human
Accession	NM_001166448.1

Human HDAC8 Gene ORF cDNA clone in cloning vector - HG10864-M from Sino Biological

Species	Human

Human HDAC8 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10864-CM from Sino Biological

Species	Human

Human HDAC8 Gene ORF cDNA clone expression plasmid, N-His tag - HG10864-NH from Sino Biological

Species	Human

Human HDAC8 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10864-M-F from Sino Biological

Species	Human

Human HDAC8 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10864-M-N from Sino Biological

Species	Human
Accession	NM_018486.1

Human HDAC8 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10864-NY from Sino Biological

Species	Human

Human HDAC8 Gene ORF cDNA clone expression plasmid, C-His tag - HG10864-CH from Sino Biological

Species	Human

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