HDAC8

Gene Symbol HDAC8
Entrez Gene 55869
Alt Symbol CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species Human
Gene Type protein-coding
Description histone deacetylase 8
Other Description histone deacetylase-like 1
Swissprots Q9BY41 Q9NYH4 A6ND61 A6NJR3 B4DKN0 Q9NP76 B4DV22 Q86VC8 A6ND12 A6NET3 A8MQ62
Accessions EAW71821 EAW71822 EAW71823 EAW71824 Q9BY41 AF212246 AAK14930 AF230097 AAF73076 AF245664 AAF73428 AI651236 AI916593 AJ277724 CAB90213 AK054936 AK074326 AK294903 BAG57992 AK296641 BAG59242 AK298767 BAG60909 AK300895 BAG62534 AY429539 BC050433 AAH50433 BF514915 BP229332 BQ189619 BQ632790 DC352390 EU446822 ABZ92351 EU832800 ACE87811 GQ129378 ACT64512 XM_011530986 XP_011529288 XM_011530987 XP_011529289 XM_011530988 XP_011529290 XR_938402 NM_001166418 NP_001159890 NM_001166419 NP_001159891 NM_001166420 NP_001159892 NM_001166422 NP_001159894 NM_001166448 NP_001159920 NM_018486 NP_060956 NR_051952
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:10922473, ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:22885700}.
Subcellular Location Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Tissue Specificity Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. {ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}.
Top Pathways Viral carcinogenesis, Alcoholism

HDAC8 Activity Assay Kit (Fluorometric) - ab156069 from Abcam

Category Cellular Assay
Prices $464.00
Sizes 100 tests
Dose dependency of recombinant HDAC8 (30min.)

Mouse/Human/Rat HDAC8 ELISA Kit (Cell-Based ELISA) - LS-F2044 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Mouse/Human/Rat Phospho-HDAC8 (Ser39) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1525 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Histone Deacetylase 8/HDAC8 Colorimetric Assay Kit - KA0631 from Novus Biologicals

Category Assay Kit
Prices $799.00
Sizes 1 kit

Histone deacetylase 8, HDAC8, Human, ELISA Kit - E1111h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 0.625-40 ng/mL

HDAC8 (Human) IP-WB Antibody Pair - H00055869-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

HDAC8 (Human) IP-WB Antibody Pair - H00055869-PW2 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

HDAC8 Colorimetric Cell-Based ELISA Kit - CB5327 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

HDAC8 (Phospho-Ser39) Colorimetric Cell-Based ELISA Kit - CBP1571 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Histone Deacetylase 8 (HDAC8), ELISA Kit - MBS9312632 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone deacetylase 8, HDAC8, ELISA Kit - MBS9305147 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone deacetylase 8, HDAC8, ELISA Kit - MBS9302102 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone deacetylase 8, HDAC8, ELISA Kit - MBS9304710 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Histone deacetylase 8, HDAC8, ELISA Kit - MBS9305231 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Bovine HDAC8 ELISA Kit (Custom ELISA) - LS-F16044 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Rat HDAC8 ELISA Kit (Custom ELISA) - LS-F16045 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Mouse HDAC8 ELISA Kit (Custom ELISA) - LS-F16046 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Human HDAC8 ELISA Kit (Custom ELISA) - LS-F16047 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Human Histone deacetylase 8 ELISA Kit - abx250518 from Abbexa

Category ELISA Kit
Range 0.625 ng/ml - 40 ng/ml

HDAC8 ELISA Kit - DEIA-XYA786 from Creative Diagnostics

Category ELISA Kit

HDAC8 (Phospho-Ser39) ELISA Kit - DEIA-XYA787 from Creative Diagnostics

Category ELISA Kit

Human Histone deacetylase 8 ELISA Kit - EKE52876 from Biomatik

Category ELISA Kit
Prices $685.40, $2,912.95, $5,483.20
Sizes 96 t, 5x96t, 10x96t
Sensitivity The minimum detectable dose of this kit is typically less than 0.32 ng/mL
Range 0.625-40 ng/mL

HDAC8 - EKH2516 from Nordic BioSite

Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

Human HDAC8 ELISA Kit - E018811 from Biobool

Category ELISA Kit
Sensitivity <0.375ng/ml

HDAC8 ELISA Kit (Human) (OKEH04451) - OKEH04451 from Aviva Systems Biology

Category ELISA Kit
Prices $596.00
Sizes 96 wells
Sensitivity < 0.31ng/mL
Range 0.63 - 40 ng/ml
Search more