HDAC8

Gene Symbol	HDAC8
Entrez Gene	55869
Alt Symbol	CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 8
Other Description	histone deacetylase-like 1
Swissprots	Q9BY41 Q9NYH4 A6ND61 A6NJR3 B4DKN0 Q9NP76 B4DV22 Q86VC8 A6ND12 A6NET3 A8MQ62
Accessions	EAW71821 EAW71822 EAW71823 EAW71824 Q9BY41 AF212246 AAK14930 AF230097 AAF73076 AF245664 AAF73428 AI651236 AI916593 AJ277724 CAB90213 AK054936 AK074326 AK294903 BAG57992 AK296641 BAG59242 AK298767 BAG60909 AK300895 BAG62534 AY429539 BC050433 AAH50433 BF514915 BP229332 BQ189619 BQ632790 DC352390 EU446822 ABZ92351 EU832800 ACE87811 GQ129378 ACT64512 XM_011530986 XP_011529288 XM_011530987 XP_011529289 XM_011530988 XP_011529290 XR_938402 NM_001166418 NP_001159890 NM_001166419 NP_001159891 NM_001166420 NP_001159892 NM_001166422 NP_001159894 NM_001166448 NP_001159920 NM_018486 NP_060956 NR_051952
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:10922473, ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:22885700}.
Subcellular Location	Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Tissue Specificity	Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. {ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}.
Top Pathways	Viral carcinogenesis, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HDAC8 peptide - ab41710 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

HDAC8 peptide - ab202289 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human HDAC8 full length protein - ab42633 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human HDAC8 peptide - ab27458 from Abcam Category Peptide

HDAC8 Antibody Blocking Peptide - LS-E735 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC8 Antibody Blocking Peptide - LS-E12283 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HDAC8 Antibody Blocking Peptide - LS-E12284 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Histone Deacetylase 8/HDAC8 Partial Recombinant Protein - H00055869-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Histone Deacetylase 8/HDAC8 Recombinant Protein - H00055869-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Histone Deacetylase 8/HDAC8 Protein - NBP1-99513 from Novus Biologicals Category Protein Prices $309.00 Sizes 20 µg Species Human

Histone Deacetylase 8/HDAC8 Protein - NBP1-99673 from Novus Biologicals Category Protein Species Human

Recombinant Human Histone Deacetylase 8/HDAC8 Protein - NBP1-78828 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

Histone Deacetylase 8/HDAC8 Peptide - P0222 from Novus Biologicals Category Peptide Species Human

HDAC8-Antibody-N-term-Blocking-Peptide - BP1108a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Histone Deacetylase 8, CF - 4359-DA-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Met1-Val377, with an N-terminal Met and 7-His tag

Human HDAC8 protein - orb244266 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human HD 8 protein - orb83564 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Insect Species Human

Human HDAC8 protein - orb168486 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

HDAC 8 Blocking Peptide - 33R-10523 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

HDAC8 Blocking Peptide - 33R-10833 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

HDAC8 protein - 30R-2816 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source Sf-9 insect cells

HDAC8 (1-377, His-tag) - AR50154PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source SF9 cells Species Human

HDAC8 (1-377, His-tag) - AR50154PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source SF9 cells Species Human

HDAC8 - H00055869-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HDAC8 - H00055869-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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