HDAC8

Gene Symbol HDAC8
Entrez Gene 55869
Alt Symbol CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species Human
Gene Type protein-coding
Description histone deacetylase 8
Other Description histone deacetylase-like 1
Swissprots Q9BY41 Q9NYH4 A6ND61 A6NJR3 B4DKN0 Q9NP76 B4DV22 Q86VC8 A6ND12 A6NET3 A8MQ62
Accessions EAW71821 EAW71822 EAW71823 EAW71824 Q9BY41 AF212246 AAK14930 AF230097 AAF73076 AF245664 AAF73428 AI651236 AI916593 AJ277724 CAB90213 AK054936 AK074326 AK294903 BAG57992 AK296641 BAG59242 AK298767 BAG60909 AK300895 BAG62534 AY429539 BC050433 AAH50433 BF514915 BP229332 BQ189619 BQ632790 DC352390 EU446822 ABZ92351 EU832800 ACE87811 GQ129378 ACT64512 XM_011530986 XP_011529288 XM_011530987 XP_011529289 XM_011530988 XP_011529290 XR_938402 NM_001166418 NP_001159890 NM_001166419 NP_001159891 NM_001166420 NP_001159892 NM_001166422 NP_001159894 NM_001166448 NP_001159920 NM_018486 NP_060956 NR_051952
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:10922473, ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:22885700}.
Subcellular Location Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Tissue Specificity Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. {ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}.
Top Pathways Viral carcinogenesis, Alcoholism

HDAC8 CRISPR/Cas9 KO Plasmid (h) - sc-400757 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 HDR Plasmid (h) - sc-400757-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 Double Nickase Plasmid (h) - sc-400757-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 Double Nickase Plasmid (h2) - sc-400757-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 CRISPR Activation Plasmid (h) - sc-400757-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 CRISPR Activation Plasmid (h2) - sc-400757-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 Lentiviral Activation Particles (h) - sc-400757-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 Lentiviral Activation Particles (h2) - sc-400757-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HDAC8 siRNA (h) - sc-35548 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HDAC8 shRNA Plasmid (h) - sc-35548-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HDAC8 shRNA (h) Lentiviral Particles - sc-35548-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HDAC8 siRNA (h2) - sc-44305 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HDAC8 shRNA Plasmid (h2) - sc-44305-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HDAC8 shRNA (h2) Lentiviral Particles - sc-44305-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU088741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9934 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9934 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04279 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04279

HDAC8 siRNA (Human) - CRJ0983 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Histone Deacetylase 8/HDAC8 RNAi - H00055869-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

HDAC8 - MBS8226945 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HDAC8 (NM_018486.2) - SHH311041 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HDAC8(NM_001166418.1) - SHH116579 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HDAC8(NM_001166448.1) - SHH116585 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human HDAC8(NM_001166420.1) - SHH116603 from Creative biogene

Category siRNA
Species Reactivities Human
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