HDAC8

Gene Symbol	HDAC8
Entrez Gene	55869
Alt Symbol	CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS
Species	Human
Gene Type	protein-coding
Description	histone deacetylase 8
Other Description	histone deacetylase-like 1
Swissprots	Q9BY41 Q9NYH4 A6ND61 A6NJR3 B4DKN0 Q9NP76 B4DV22 Q86VC8 A6ND12 A6NET3 A8MQ62
Accessions	EAW71821 EAW71822 EAW71823 EAW71824 Q9BY41 AF212246 AAK14930 AF230097 AAF73076 AF245664 AAF73428 AI651236 AI916593 AJ277724 CAB90213 AK054936 AK074326 AK294903 BAG57992 AK296641 BAG59242 AK298767 BAG60909 AK300895 BAG62534 AY429539 BC050433 AAH50433 BF514915 BP229332 BQ189619 BQ632790 DC352390 EU446822 ABZ92351 EU832800 ACE87811 GQ129378 ACT64512 XM_011530986 XP_011529288 XM_011530987 XP_011529289 XM_011530988 XP_011529290 XR_938402 NM_001166418 NP_001159890 NM_001166419 NP_001159891 NM_001166420 NP_001159892 NM_001166422 NP_001159894 NM_001166448 NP_001159920 NM_018486 NP_060956 NR_051952
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. {ECO:0000269|PubMed:10748112, ECO:0000269|PubMed:10922473, ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:22885700}.
Subcellular Location	Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Tissue Specificity	Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. {ECO:0000269|PubMed:10926844, ECO:0000269|PubMed:14701748, ECO:0000269|PubMed:15772115, ECO:0000269|PubMed:16538051}.
Top Pathways	Viral carcinogenesis, Alcoholism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HDAC8-Over-expression-Lysate - LY11880a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

HDAC8 293T Cell Transient Overexpression Lysate(Denatured) - H00055869-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

HDAC8 overexpression lysate - LY413013 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HDAC8 overexpression lysate - LY432831 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HDAC8 293 Cell Lysate - 406310 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Histone Deacetylase 8/HDAC8 Overexpression Lysate (Denatured) - H00055869-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Histone Deacetylase 8/HDAC8 Overexpression Lysate (Native) - NBL1-11485 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HDAC8 (h2): 293T Lysate - sc-177327 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

HDAC8 Over-expression Lysate Product - GWB-4351EF from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human HDAC8 / HDACL1 Insect Cell Lysate (WB positive control) - 10864-H09BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human HDAC8 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174942 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

HDAC8-knockout Cell lysate - LC810372 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human HDAC8 Knockdown Stable Cell Line - CSC-DC006893 from Creative biogene Category Cell Line Species Human

Human HDAC8 Knockout Cell Line-HeLa - CSC-RT0761 from Creative biogene Category Cell Line Species Human

HDAC8 KO Cell Lysate-HeLa - CLKO-0265 from Creative biogene Category Cell Lysate

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