PADI4

Gene Symbol	PADI4
Entrez Gene	23569
Alt Symbol	PAD, PAD4, PADI5, PDI4, PDI5
Species	Human
Gene Type	protein-coding
Description	peptidyl arginine deiminase, type IV
Other Description	HL-60 PAD|PADI-H protein|peptidyl arginine deiminase, type V|protein-arginine deiminase type IV|protein-arginine deiminase type-4
Swissprots	B2RBW0 Q70SX4 Q5VTZ8 Q9UM07 A8K392
Accessions	CAE47743 CAG30581 CAG30582 CAG30583 CAG30584 CAG30585 CAG30586 CAG30587 CAI84651 EAW94835 EAW94836 Q9UM07 AB017919 BAA84542 AF229067 AAF82265 AK290507 BAF83196 AK309637 AK314839 BAG37357 BC025718 AAH25718 JF432820 ADZ16037 XM_011541150 XP_011539452 XM_011541151 XP_011539453 XM_011541152 XP_011539454 XM_011541153 XP_011539455 XM_011541154 XP_011539456 XM_011541155 XP_011539457 XM_011541156 XP_011539458 XM_011541157 XP_011539459 XM_011548837 XP_011547139 XM_011548838 XP_011547140 XM_011548839 XP_011547141 XM_011548840 XP_011547142 XM_011548841 XP_011547143 XM_011548842 XP_011547144 XM_011548843 XP_011547145 XM_011548844 XP_011547146 NM_012387 NP_036519
Function	Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg- 54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCO
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils.
Tissue Specificity	Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. {ECO:0000269|PubMed:11435484}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PADI4 overexpression lysate - LY402202 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PADI4 293 Cell Lysate - 401937 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PADI4 (h): 293T Lysate - sc-114204 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PADI4 Over-expression Lysate Product - GWB-B4AA70 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human PAD4 / PADI4 Insect Cell Lysate (WB positive control) - 11072-H07BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

PADI4 Overexpression Lysate (Native) - NBL1-14061 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PADI4 Overexpression Lysate (Denatured) - H00023569-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Human PAD4 Baculovirus-Insect cells Transfected Lysate (positive control) (denatured) - orb232867 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human PADI4 Knockdown Stable Cell Line - CSC-DC011240 from Creative biogene Category Cell Line Species Human

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