PADI4

Gene Symbol	PADI4
Entrez Gene	23569
Alt Symbol	PAD, PAD4, PADI5, PDI4, PDI5
Species	Human
Gene Type	protein-coding
Description	peptidyl arginine deiminase, type IV
Other Description	HL-60 PAD|PADI-H protein|peptidyl arginine deiminase, type V|protein-arginine deiminase type IV|protein-arginine deiminase type-4
Swissprots	B2RBW0 Q70SX4 Q5VTZ8 Q9UM07 A8K392
Accessions	CAE47743 CAG30581 CAG30582 CAG30583 CAG30584 CAG30585 CAG30586 CAG30587 CAI84651 EAW94835 EAW94836 Q9UM07 AB017919 BAA84542 AF229067 AAF82265 AK290507 BAF83196 AK309637 AK314839 BAG37357 BC025718 AAH25718 JF432820 ADZ16037 XM_011541150 XP_011539452 XM_011541151 XP_011539453 XM_011541152 XP_011539454 XM_011541153 XP_011539455 XM_011541154 XP_011539456 XM_011541155 XP_011539457 XM_011541156 XP_011539458 XM_011541157 XP_011539459 XM_011548837 XP_011547139 XM_011548838 XP_011547140 XM_011548839 XP_011547141 XM_011548840 XP_011547142 XM_011548841 XP_011547143 XM_011548842 XP_011547144 XM_011548843 XP_011547145 XM_011548844 XP_011547146 NM_012387 NP_036519
Function	Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg- 54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCO
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils.
Tissue Specificity	Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. {ECO:0000269|PubMed:11435484}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PADI4 / PAD4 full length protein - ab196393 from Abcam Category Protein Prices $1,250.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PADI4 / PAD4 full length protein - ab126910 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human PADI4 / PAD4 full length protein - ab161695 from Abcam Category Protein Source Wheat germ Species Human

Human PADI4 / PAD4 full length protein - ab173032 from Abcam Category Protein Source E. coli Species Human

Human PADI4 / PAD4 peptide - ab38771 from Abcam Category Peptide

Human PADI4 / PAD4 peptide - ab30475 from Abcam Category Peptide Species Human

Human PADI4 / PAD4 protein fragment - ab161696 from Abcam Category Protein Source Wheat germ Species Human

PADI4 / PAD4 peptide - ab156172 from Abcam Category Peptide

PADI4 / PAD4 Antibody Blocking Peptide - LS-E25790 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PADI4 / PAD4 Antibody Blocking Peptide - LS-E7003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PADI4 / PAD4 Antibody Blocking Peptide - LS-E19792 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PADI4 Recombinant Protein - H00023569-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PADI4 Protein - H00023569-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PADI4 Peptide - P0189 from Novus Biologicals Category Peptide Species Human

PADI4 Peptide - P1167 from Novus Biologicals Category Peptide Species Human

PAD4-Antibody-Center-Blocking-Peptide - BP1072c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAD4-Antibody-C-term-Blocking-Peptide - BP2546b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAD4/PADI4 blocking peptide - GTX89631-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human PADI4, CF - 6660-AD-010 from R&D Systems Category Protein Source E. coli-derived, Ala2-Pro663, with an N-terminal 11 kDa fusion protein, a thrombin cleavage linker and a C-terminal 6-His tag

Human PADI4 His GST tag protein - orb84079 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Insect Species Human

Human PAD4 (His Tag) protein - orb232259 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 10 μg, 50 μg Species Human

Goat anti PADI4 antibody Immunizing peptide - orb17023 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PADI4 Blocking Peptide - 33R-9085 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PADI4 / PAD4 Peptide - AC21-0620-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PADI4 - H00023569-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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