PADI4

Gene Symbol	PADI4
Entrez Gene	23569
Alt Symbol	PAD, PAD4, PADI5, PDI4, PDI5
Species	Human
Gene Type	protein-coding
Description	peptidyl arginine deiminase, type IV
Other Description	HL-60 PAD|PADI-H protein|peptidyl arginine deiminase, type V|protein-arginine deiminase type IV|protein-arginine deiminase type-4
Swissprots	B2RBW0 Q70SX4 Q5VTZ8 Q9UM07 A8K392
Accessions	CAE47743 CAG30581 CAG30582 CAG30583 CAG30584 CAG30585 CAG30586 CAG30587 CAI84651 EAW94835 EAW94836 Q9UM07 AB017919 BAA84542 AF229067 AAF82265 AK290507 BAF83196 AK309637 AK314839 BAG37357 BC025718 AAH25718 JF432820 ADZ16037 XM_011541150 XP_011539452 XM_011541151 XP_011539453 XM_011541152 XP_011539454 XM_011541153 XP_011539455 XM_011541154 XP_011539456 XM_011541155 XP_011539457 XM_011541156 XP_011539458 XM_011541157 XP_011539459 XM_011548837 XP_011547139 XM_011548838 XP_011547140 XM_011548839 XP_011547141 XM_011548840 XP_011547142 XM_011548841 XP_011547143 XM_011548842 XP_011547144 XM_011548843 XP_011547145 XM_011548844 XP_011547146 NM_012387 NP_036519
Function	Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg- 54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCO
Subcellular Location	Cytoplasm. Nucleus. Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils and neutrophils.
Tissue Specificity	Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. {ECO:0000269|PubMed:11435484}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PADI4 gene - orb91703 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-PADI4-cDNA-Clone - DC05510 from Abgent, a WuXi AppTec company Prices $895.05 Sizes 10 µg Species Human Accession BC025718

PADI4 - MBS1273516 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC025718

Human PADI4 ORF clone(NM_012387.2) - CDCL185595 from Creative Biomart Species Human Accession NM_012387.2

Human PAD4/PADI4 Gene ORF cDNA clone in cloning vector - HG11072-M from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid - HG11072-UT from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, N-His tag - HG11072-NH from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11072-ANG from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11072-ACG from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, C-His tag - HG11072-CH from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11072-NF from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11072-M-M from Sino Biological Species Human

Human PADI4 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11072-M-N from Sino Biological Species Human Accession NM_012387.2

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11072-NM from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11072-CF from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11072-CM from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11072-ACR from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11072-ANR from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11072-CY from Sino Biological Species Human

Human PAD4/PADI4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11072-NY from Sino Biological Species Human

Human PADI4 ORF clone(NM_012387.2) - CDCL185595 from Creative biogene Species Human

Human PADI4 ORF Clone (BC025718) - CDCS413315 from Creative biogene Species Human Accession Q9UM07

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