| Gene Symbol |
CYR61
|
| Entrez Gene |
3491
|
| Alt Symbol |
CCN1, GIG1, IGFBP10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cysteine-rich, angiogenic inducer, 61
|
| Other Description |
CCN family member 1|IBP-10|IGF-binding protein 10|IGFBP-10|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61|insulin-like growth factor-binding protein 10|protein CYR61
|
| Swissprots |
O43775 Q9BZL7 O14934 O00622
|
| Accessions |
AAG59863 AAR05446 EAW73196 EAW73197 EAW73198 O00622 AF003114 AAF21597 AF003594 AAB61240 AF031385 AAB84227 AK096420 AK223385 BAD97105 AK295430 BAG58373 AK314571 BAG37152 AL832891 BC001271 AAH01271 BC009199 AAH09199 BC016952 AAH16952 BP387218 CR536519 CAG38757 DA764894 DQ891262 ABM82188 DQ894449 ABM85375 U62015 AAB58319 Y11307 CAA72167 Y12084 CAA72802 Z50168 Z97068 CAB09804 Z98053 CAB10848 NM_001554 NP_001545
|
| Function |
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
|
| Subcellular Location |
Secreted.
|
![Western Blot: CYR61 Overexpression Lysate (Adult Normal) [NBL1-09705] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CYR61.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6693_CYR61%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09705-img0001.jpg)