CYR61

Gene Symbol CYR61
Entrez Gene 3491
Alt Symbol CCN1, GIG1, IGFBP10
Species Human
Gene Type protein-coding
Description cysteine-rich, angiogenic inducer, 61
Other Description CCN family member 1|IBP-10|IGF-binding protein 10|IGFBP-10|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61|insulin-like growth factor-binding protein 10|protein CYR61
Swissprots O43775 Q9BZL7 O14934 O00622
Accessions AAG59863 AAR05446 EAW73196 EAW73197 EAW73198 O00622 AF003114 AAF21597 AF003594 AAB61240 AF031385 AAB84227 AK096420 AK223385 BAD97105 AK295430 BAG58373 AK314571 BAG37152 AL832891 BC001271 AAH01271 BC009199 AAH09199 BC016952 AAH16952 BP387218 CR536519 CAG38757 DA764894 DQ891262 ABM82188 DQ894449 ABM85375 U62015 AAB58319 Y11307 CAA72167 Y12084 CAA72802 Z50168 Z97068 CAB09804 Z98053 CAB10848 NM_001554 NP_001545
Function Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
Subcellular Location Secreted.

CYR61 (D4H5D) XP ® Rabbit mAb - 14479 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4H5D
Western blot analysis of extracts from various cell lines using CYR61 (D4H5D) XP ® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). As expected, MCF7 cells are negative for CYR61 expression.

CYR61 Antibody - 11952 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

Cyr61 (A-10) - sc-374129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cyr61 (A-10): sc-374129. Western blot analysis of Cyr61 expression in non-transfected: sc-110760 (A) and human Cyr61 transfected: sc-113135 (B) 293 whole cell lysates.

Cyr61 (K-13) - sc-34775 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cyr61 (N-16) - sc-8560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cyr61 (N-16): sc-8560. Western blot analysis of Cyr61 expression in non-transfected: sc-110760 (A) and human Cyr61 transfected: sc-113135 (B) 293 whole cell lysates.

Cyr61 (H-2) - sc-271217 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cyr61 (H-2): sc-271217. Western blot analysis of Cyr61 expression in non-transfected: sc-117752 (A) and human Cyr61 transfected: sc-175194 (B) 293T whole cell lysates.

Cyr61 (H-78) - sc-13100 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cyr61 (H-78): sc-13100. Western blot analysis of Cyr61 expression in non-transfected: sc-110760 (A) and human Cyr61 transfected: sc-113135 (B) 293 whole cell lysates.

Cyr61 (C-20) - sc-8561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cyr61 (S-12) - sc-34776 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cyr61 (S-12): sc-34776. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

Anti-CCN1 antibody - ab10760 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab10760 staining CCN1 in mouse kidney tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin embedded). Tissue underwent fixation in formaldehyde, heat-mediated antigen retrieval in Tris-EDTA buffer pH9.0 and bloking for 15 minutes at 20°C (5 minutes/peroxidase block and 10 minutes/protein block). The primary antibody was diluted 1/100 and incubated with sample for 45 minutes at 20°C. A HRP-conjugated goat polyclonal to rabbit IgG was used, undiluted as the secondary.  See Abreview

Anti-CCN1 antibody - ab14237 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-CCN1 antibody - ab127988 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab127988 at 1/100 dilution staining CCN1 in paraffin embedded Human endometrium tissue by Immunohistochemistry.

Anti-CCN1 antibody [3H3] - ab80112 from Abcam

Prices $394.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H3
Anti-CCN1 antibody [3H3] (ab80112) at 1/250 dilution + Jurkat cell lysate at 40 µgSecondarygoat anti-mouse HRPdeveloped using the ECL technique

Anti-CCN1 antibody, prediluted - ab82040 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab82040, prediluted, staining CCN1 in formalin fixed, paraffin embedded human placenta tissue by Immunohistochemistry.

Anti-CYR61 Antibody (aa176-379) - LS-C293625 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CYR61.

Anti-CYR61 Antibody (aa178-381) - LS-C293624 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CYR61.

Anti-CYR61 Antibody (aa100-149) - LS-C205633 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYR61 antibody Western Blot of COLO205. Antibody dilution: 3 ug/ml.

Anti-CYR61 Antibody (aa22-381, clone 365108) - LS-C347587 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 365108

Anti-CYR61 Antibody - LS-C335126 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot analysis of Jurkat cell lysate using CYR61 antibody.

Anti-CYR61 Antibody (aa176-281, clone 466305) - LS-C347589 from LifeSpan Bioscience

Host Rat
Clonality Monoclonal
Clone 466305

Anti-CYR61 Antibody (aa168-242, clone 3H3) IHC-plus™ - LS-B2959 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3H3
Anti-CYR61 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2959 concentration 5 ug/ml.

Anti-CYR61 Antibody (Internal) - LS-C210523 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunohistochemistry of Human Colon stained with anti-CYR61 antibody

Anti-CYR61 Antibody IHC-plus™ - LS-B8746 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CYR61 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CYR61 Antibody (aa47-332) IHC-plus™ - LS-B11602 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Human Colon, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CYR61 Antibody (aa150-250) - LS-C64179 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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