CYR61

Gene Symbol	CYR61
Entrez Gene	3491
Alt Symbol	CCN1, GIG1, IGFBP10
Species	Human
Gene Type	protein-coding
Description	cysteine-rich, angiogenic inducer, 61
Other Description	CCN family member 1|IBP-10|IGF-binding protein 10|IGFBP-10|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61|insulin-like growth factor-binding protein 10|protein CYR61
Swissprots	O43775 Q9BZL7 O14934 O00622
Accessions	AAG59863 AAR05446 EAW73196 EAW73197 EAW73198 O00622 AF003114 AAF21597 AF003594 AAB61240 AF031385 AAB84227 AK096420 AK223385 BAD97105 AK295430 BAG58373 AK314571 BAG37152 AL832891 BC001271 AAH01271 BC009199 AAH09199 BC016952 AAH16952 BP387218 CR536519 CAG38757 DA764894 DQ891262 ABM82188 DQ894449 ABM85375 U62015 AAB58319 Y11307 CAA72167 Y12084 CAA72802 Z50168 Z97068 CAB09804 Z98053 CAB10848 NM_001554 NP_001545
Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
Subcellular Location	Secreted.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-CYR61-cDNA-Clone - DC00592 from Abgent, a WuXi AppTec company Prices $514.35 Sizes 10 µg Species Human Accession BC001271

CYR61 cDNA (ANA10384) - ANA10384 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC016952

CYR61 cDNA (ANA10385) - ANA10385 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession BC016952

CYR61 - MBS1267364 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC001271

Human CYR61 ORF clone(NM_001554.4) - CDCL183872 from Creative Biomart Species Human Accession NM_001554.4

Human CYR61 ORF Clone(NM_001554.4) - CDCL160430 from Creative Biomart Species Human Accession NM_001554.4

Human CYR61 ORF clone(NM_001554.4) - CDCL183872 from Creative biogene Species Human

Human CYR61 ORF Clone (BC001271) - CDCS410318 from Creative biogene Species Human Accession O00622

Human CCN1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11606-CF from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11606-ACR from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11606-NM from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11606-NH from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone in cloning vector - HG11606-M from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11606-CM from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11606-ACG from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11606-NY from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11606-CY from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11606-NF from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid - HG11606-UT from Sino Biological Species Human

Human CCN1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11606-CH from Sino Biological Species Human

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