CYR61

Gene Symbol	CYR61
Entrez Gene	3491
Alt Symbol	CCN1, GIG1, IGFBP10
Species	Human
Gene Type	protein-coding
Description	cysteine-rich, angiogenic inducer, 61
Other Description	CCN family member 1|IBP-10|IGF-binding protein 10|IGFBP-10|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61|insulin-like growth factor-binding protein 10|protein CYR61
Swissprots	O43775 Q9BZL7 O14934 O00622
Accessions	AAG59863 AAR05446 EAW73196 EAW73197 EAW73198 O00622 AF003114 AAF21597 AF003594 AAB61240 AF031385 AAB84227 AK096420 AK223385 BAD97105 AK295430 BAG58373 AK314571 BAG37152 AL832891 BC001271 AAH01271 BC009199 AAH09199 BC016952 AAH16952 BP387218 CR536519 CAG38757 DA764894 DQ891262 ABM82188 DQ894449 ABM85375 U62015 AAB58319 Y11307 CAA72167 Y12084 CAA72802 Z50168 Z97068 CAB09804 Z98053 CAB10848 NM_001554 NP_001545
Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
Subcellular Location	Secreted.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDK1 + Cyclin A2 full length protein - ab64299 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human CDK2 + Cyclin A2 full length protein - ab51407 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

CCN1 peptide - ab52125 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human CCN1 full length protein - ab131868 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CCN1 full length protein - ab191971 from Abcam Category Protein Prices $196.00 Sizes 10 µg Source HEK 293 cells Species Human

Human CCN1 peptide - ab24416 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CCN1 protein fragment - ab79550 from Abcam Category Protein Prices $188.00 Sizes 250 µg Source E. coli Species Human

Human CCN1 protein fragment - ab50074 from Abcam Category Protein Prices $110.00, $235.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Cyr61/CCN1 Recombinant Protein - H00003491-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human Cyr61/CCN1 Protein - NBP2-34944 from Novus Biologicals Category Protein Prices $69.00, $169.00, $879.00, $3,469.00 Sizes 5 µg, 20 µg, 250 µg, 1 mg Source E. coli Species Human

Recombinant Human Cyr61/CCN1 Protein - H00003491-P02 from Novus Biologicals Category Protein Prices $319.00, $369.00 Sizes 2 µg, 10 µg Source Wheat Germ Species Human

Cyr61/CCN1 Partial Recombinant Protein - H00003491-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CYR61 Recombinant Protein (Active) - GTX48189-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

Recombinant Human Cyr61/CCN1 Fc Chimera, CF - 4055-CR-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

CYR61 Protein Lysate (APL10384) - APL10384 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

CYR61 Protein Lysate (APL10385) - APL10385 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human CYR61 protein - orb107703 from Biorbyt Category Protein Prices $221.00, $357.00, $689.00, $1,165.00 Sizes 5 μg, 20 μg, 100 μg, 250 μg Source E.coli Species Human

Human CYR61 protein - orb168186 from Biorbyt Category Protein Prices $187.00, $323.00, $4,046.00 Sizes 5 μg, 20 μg, 1 mg Species Human, Mouse

Human CYR61 protein - orb180241 from Biorbyt Category Protein Prices $306.00, $400.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Cyr61 Blocking Peptide - 33R-10534 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

Cyr61 Blocking Peptide - 33R-10855 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

CYR61 protein - 30R-AC076 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg Source E.coli

Human CYR61 Protein - abx066246 from Abbexa Category Protein Source E.coli Species Human

CYR61 - AR31100PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 20 µg Source E. coli Species Human

CYR61 - AR31100PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source E. coli Species Human

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