CYR61

Gene Symbol CYR61
Entrez Gene 3491
Alt Symbol CCN1, GIG1, IGFBP10
Species Human
Gene Type protein-coding
Description cysteine-rich, angiogenic inducer, 61
Other Description CCN family member 1|IBP-10|IGF-binding protein 10|IGFBP-10|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61|insulin-like growth factor-binding protein 10|protein CYR61
Swissprots O43775 Q9BZL7 O14934 O00622
Accessions AAG59863 AAR05446 EAW73196 EAW73197 EAW73198 O00622 AF003114 AAF21597 AF003594 AAB61240 AF031385 AAB84227 AK096420 AK223385 BAD97105 AK295430 BAG58373 AK314571 BAG37152 AL832891 BC001271 AAH01271 BC009199 AAH09199 BC016952 AAH16952 BP387218 CR536519 CAG38757 DA764894 DQ891262 ABM82188 DQ894449 ABM85375 U62015 AAB58319 Y11307 CAA72167 Y12084 CAA72802 Z50168 Z97068 CAB09804 Z98053 CAB10848 NM_001554 NP_001545
Function Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
Subcellular Location Secreted.

Cyr61 CRISPR/Cas9 KO Plasmid (h) - sc-400366 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 HDR Plasmid (h) - sc-400366-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 Double Nickase Plasmid (h) - sc-400366-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 Double Nickase Plasmid (h2) - sc-400366-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 CRISPR Activation Plasmid (h) - sc-400366-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 CRISPR Activation Plasmid (h2) - sc-400366-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 Lentiviral Activation Particles (h) - sc-400366-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 Lentiviral Activation Particles (h2) - sc-400366-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cyr61 siRNA (h) - sc-39331 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cyr61 shRNA Plasmid (h) - sc-39331-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cyr61 shRNA (h) Lentiviral Particles - sc-39331-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU089921 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1998 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1998 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06129 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06129

CYR61 siRNA (Human) - CRH2362 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYR61 - MBS8228230 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CYR61 (NM_001554.4) - SHH273853 from Creative biogene

Category siRNA
Species Reactivities Human

Human CYR61 siRNA - orb262864 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CYR61 shRNA Plasmid (Human) - CHH2362 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CYR61 miRNA 3'UTR clone - MiUTR3H-04916 from Creative biogene

Species Reactivities Human
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