XBP1

Gene Symbol	XBP1
Entrez Gene	7494
Alt Symbol	TREB-5, TREB5, XBP-1, XBP2
Species	Human
Gene Type	protein-coding
Description	X-box binding protein 1
Other Description	X-box-binding protein 1|tax-responsive element-binding protein 5
Swissprots	Q969P1 Q96BD7 P17861 Q8WYK6
Accessions	CAA39149 EAW59763 EAW59764 EAW59765 P17861 AB076383 BAB82981 AB076384 BAB82982 AK093842 AK292188 BAF84877 AK313761 AM393640 CAL38516 BC000938 AAH00938 BC012841 AAH12841 BC015709 AAH15709 BI545390 CR456611 CAG30497 CU013207 CAK54638 CU013495 CAK54937 DQ890989 ABM81915 DQ894165 ABM85091 M31627 AAA36031 NM_001079539 NP_001073007 NM_005080 NP_005071
Function	Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis
Subcellular Location	Isoform 2: Nucleus {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin- dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.
Tissue Specificity	Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). {ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:25280941}.
Top Pathways	Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human XBP1 ELISA Kit (Sandwich ELISA) - LS-F6812 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

Mouse XBP1 ELISA Kit (Sandwich ELISA) - LS-F7625 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.156-10 ng/ml

Rat XBP1 ELISA Kit (Sandwich ELISA) - LS-F9843 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 0.156-10 ng/ml

Human XBP1 ELISA Kit (Sandwich ELISA) - LS-F12982 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

X-Box Binding Protein 1 (XBP1), Human, ELISA Kit - SEC605Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.063ng/mL Range 0.156-10ng/mL

X-box-binding protein 1 (XBP1), Human, ELISA Kit - CSB-EL026183HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

X-box-binding protein 1, XBP1, Human, ELISA Kit - E9143h from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 ng/mL

X-Box Binding Protein 1 (XBP1), Human, CLIA Kit - SCC605Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.047ng/mL Range 0.156-10ng/mL

XBP1 (Human) IP-WB Antibody Pair - H00007494-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

X Box Binding Protein 1, ELISA Kit - MBS733944 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

X-Box Binding Protein 1, ELISA Kit - MBS035590 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS043018 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 10pg/ml. Range 62.5pg/ml-2000pg/ml.

X-Box Binding Protein 1, ELISA Kit - MBS014603 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS068110 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS038946 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS101711 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS065898 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS016757 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS063096 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS015998 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS025999 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS009624 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Box Binding Protein 1, ELISA Kit - MBS018072 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-box binding protein 1, ELISA Kit - MBS918957 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.12 pg/ml Range 12.5 pg/ml-800 pg/ml

X-Box Binding Protein 1, ELISA Kit - MBS070317 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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