| Gene Symbol | XBP1 |
|---|---|
| Entrez Gene | 7494 |
| Alt Symbol | TREB-5, TREB5, XBP-1, XBP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | X-box binding protein 1 |
| Other Description | X-box-binding protein 1|tax-responsive element-binding protein 5 |
| Swissprots | Q969P1 Q96BD7 P17861 Q8WYK6 |
| Accessions | CAA39149 EAW59763 EAW59764 EAW59765 P17861 AB076383 BAB82981 AB076384 BAB82982 AK093842 AK292188 BAF84877 AK313761 AM393640 CAL38516 BC000938 AAH00938 BC012841 AAH12841 BC015709 AAH15709 BI545390 CR456611 CAG30497 CU013207 CAK54638 CU013495 CAK54937 DQ890989 ABM81915 DQ894165 ABM85091 M31627 AAA36031 NM_001079539 NP_001073007 NM_005080 NP_005071 |
| Function | Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11779464, PubMed:25239945). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation (By similarity). Induces phospholipid biosynthesis and ER expansion (PubMed:15466483). Contributes to the VEGF-induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression (PubMed:23529610). Promotes umbilical vein EC apoptosis |
| Subcellular Location | Isoform 2: Nucleus {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin- dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}. |
| Tissue Specificity | Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). {ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:25280941}. |
| Top Pathways | Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD) |
XBP-1 CRISPR/Cas9 KO Plasmid (h) - sc-400131 from Santa Cruz Biotechnology
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XBP-1 HDR Plasmid (h) - sc-400131-HDR from Santa Cruz Biotechnology
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XBP-1 Double Nickase Plasmid (h) - sc-400131-NIC from Santa Cruz Biotechnology
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XBP-1 Double Nickase Plasmid (h2) - sc-400131-NIC-2 from Santa Cruz Biotechnology
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XBP-1 CRISPR Activation Plasmid (h) - sc-400131-ACT from Santa Cruz Biotechnology
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XBP-1 CRISPR Activation Plasmid (h2) - sc-400131-ACT-2 from Santa Cruz Biotechnology
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XBP-1 Lentiviral Activation Particles (h) - sc-400131-LAC from Santa Cruz Biotechnology
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XBP-1 Lentiviral Activation Particles (h2) - sc-400131-LAC-2 from Santa Cruz Biotechnology
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XBP-1 siRNA (h) - sc-38627 from Santa Cruz Biotechnology
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XBP-1 shRNA Plasmid (h) - sc-38627-SH from Santa Cruz Biotechnology
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XBP-1 shRNA (h) Lentiviral Particles - sc-38627-V from Santa Cruz Biotechnology
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XBP1 RNAi - H00007494-R01 from Novus Biologicals
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MISSION® esiRNA - EHU069131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22952 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22952 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07557 from Sigma-Aldrich
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XBP1 siRNA (Human) - CRH5127 from Cohesion Biosciences
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XBP1 - MBS8223378 from MyBioSource
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shRNA set against Human Xbp1 (NM_005080.3) - SHH447692 from Creative biogene
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shRNA set against Human XBP1(NM_001079539.1) - SHL137548 from Creative biogene
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XBP1 shRNA Plasmid (Human) - CHH5127 from Cohesion Biosciences
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XBP1 miRNA 3'UTR clone - MiUTR1H-11301 from Creative biogene
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XBP1 miRNA 3'UTR clone - MiUTR3H-02417 from Creative biogene
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